product summary
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company name :
MyBioSource
product type :
antibody
product name :
ORAI1 Antibody
catalog :
MBS150221
quantity :
0.1 mg
price :
345 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, ELISA, immunohistochemistry, enzyme immunoassay
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS150221
products type :
Antibody
products full name :
ORAI1 Antibody
products short name :
ORAI1
products name syn :
ORAI1; IMD9; ORAT1; CRACM1; TMEM142A; Calcium release-activated calcium channel protein 1; Protein orai-1; ORAI calcium release-activated calcium modulator 1
other names :
Calcium release-activated calcium channel protein 1; Calcium release-activated calcium channel protein 1; calcium release-activated calcium channel protein 1; protein orai-1; transmembrane protein 142A; calcium release-activated calcium modulator 1; ORAI calcium release-activated calcium modulator 1; Protein orai-1; Transmembrane protein 142A
products gene name :
ORAI1
other gene names :
ORAI1; ORAI1; IMD9; TAM2; ORAT1; CRACM1; TMEM142A; CRACM1; TMEM142A
uniprot entry name :
CRCM1_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human, Mouse
sequence length :
301
specificity :
This antibody is predicted to have no cross-reactivity to ORAI2 or ORAI3.
purity :
ORAI1 Antibody is affinity chromatography purified via peptide column.
form :
Liquid
concentration :
1 mg/mL
storage stability :
ORAI1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
tested application :
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
app notes :
ORAI1 antibody can be used for detection of ORAI1 by Western blot at 0.5 - 2 mug/mL. ORAI1 often migrates at a higher than expected molecular weight in SDS-PAGE. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL.
other info1 :
Conjugate: Unconjugated. Immunogen: ORAI1 antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human ORAI1. Buffer: ORAI1 Antibody is supplied in PBS containing 0.02% sodium azide.
products description :
ORAI1 Antibody: Antigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. ORAI1 is a recently identified four-transmembrane spanning protein that is an essential component of CRAC. A missense mutation in this protein in humans is the cause of one form of hereditary severe combined immune deficiency (SCID) which results in ablated T-cell Ca++ entry. It has been suggested that ORAI1 functions as a highly selective Ca++ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor.
ncbi gi num :
97180269
ncbi acc num :
Q96D31.2
uniprot acc num :
Q96D31
ncbi mol weight :
25,337 Da
ncbi pathways :
Adaptive Immune System Pathway 366160!!Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway 576249!!Calcium Signaling Pathway 83050!!Calcium Signaling Pathway 459!!Elevation Of Cytosolic Ca2+ Levels Pathway 106047!!Hemostasis Pathway 106028!!Immune System Pathway 106386!!Platelet Activation Pathway 952858!!Platelet Calcium Homeostasis Pathway 187202!!Platelet Homeostasis Pathway 187198
ncbi summary :
The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1). [provided by RefSeq, Sep 2011]
size :
0.1 mg
price :
345 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

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