catalog number :
MBS150212
products full name :
Dact2 Antibody
products short name :
Dact2
products name syn :
Dact2; DPR2; DAPPER2; C6orf116; bA503C24.7; PP13671; Dapper homolog 2; Dapper antagonist of catenin 2; dapper, antagonist of beta-catenin, homolog 2 (Xenopus laevis)
other names :
dapper homolog 2 isoform a; Dapper homolog 2; dapper homolog 2; dapper antagonist of catenin 2; dapper homolog 2, antagonist of beta-catenin; dapper, antagonist of beta-catenin, homolog 2; dishevelled-binding antagonist of beta-catenin 2; Dapper antagonist of catenin 2
products gene name :
DACT2
other gene names :
DACT2; DACT2; DPR2; DAPPER2; C6orf116; bA503C24.7; C6orf116
uniprot entry name :
DACT2_HUMAN
reactivity :
Human, Mouse, Rat
purity :
Dact2 Antibody is affinity chromatography purified via peptide column.
storage stability :
Dact2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
tested application :
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
app notes :
Dact2 antibody can be used for detection of Dact2 by Western blot at 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.
other info1 :
Conjugate: Unconjugated. Immunogen: Dact2 antibody was raised against a 12 amino acid synthetic peptide from near the amino terminus of human DACT2. Buffer: Dact2 Antibody is supplied in PBS containing 0.02% sodium azide.
products description :
Dact2 Antibody: The Wnt signaling cascade is a conserved process in multicellular animals that plays important roles during development and can contribute to cancer and other diseases. Many members of this pathway are also expressed in the postnatal tissues such as brain. One such protein is Dact2, a member of the Dact protein family that was initially identified through binding to Disheveled (Dvl), a cytoplasmic protein essential to Wnt signaling. Dact2 is most prominent during the development of the thymus kidneys, and salivary gland. Dact2 is thought to play a role distinct from that of Dact1 with Dact2 having a greater impact on a beta-catenin-independent process termed planar cell polarity/convergent-extension signaling. Furthermore, Dact2 but not Dact1 can inhibit Nodal signaling by promoting the endocytic degradation of TGF-beta receptors. At least two isoforms of Dact2 are known to exist.
ncbi gb acc num :
NM_214462.4
ncbi mol weight :
29,350 Da
ncbi pathways :
TGF-beta Receptor Signaling Pathway 138024