catalog number :
MBS150189
products full name :
Prosapip1 Antibody
products short name :
Prosapip1
products name syn :
Prosapip1; PROSAPIP1; KIAA0552; PROSAPIP1; Leucine zipper putative tumor suppressor 3; ProSAP-interacting protein 1; ProSAPiP1; ProSAPiP1 protein
other names :
Leucine zipper putative tumor suppressor 3; leucine zipper putative tumor suppressor 3; ProSAP-interacting protein 1; ProSAPiP1
products gene name :
ProSAPiP1
other gene names :
LZTS3; LZTS3; PROSAPIP1; KIAA0552; PROSAPIP1; ProSAPiP1
uniprot entry name :
LZTS3_HUMAN
reactivity :
Human, Mouse, Rat
purity :
Prosapip1 Antibody is affinity chromatography purified via peptide column.
storage stability :
Prosapip1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
tested application :
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
app notes :
Prosapip1 antibody can be used for detection of Prosapip1 by Western blot at 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.
other info1 :
Conjugate: Unconjugated. Immunogen: Prosapip1 antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human Prosapip1. Buffer: Prosapip1 Antibody is supplied in PBS containing 0.02% sodium azide.
products description :
Prosapip1 Antibody: Prosapip1 is a binding partner of the postsynaptic density (PSD) protein ProSAP2/Shank3, a major scaffolding protein in excitatory brain synapses. Prosapip1 is thought to bind ProSAP2/Shank3 through ProSAP2/Shank3's PDZ domain and link it in turn to the Spine-associated Rap-Gap (SPAR). Prosapip1 shares significant homology with another PSD protein, PSD-Zip70, with both coding for a Fez1 domain that can be found in a total of four related protein, forming a novel family of scaffolding molecules termed 'Fezzins'. Recent studies show that Prosapip1 can be found in endocrine cells in which it is localized primarily in the hormone-storing compartment of these cells, suggesting that Prosapip1 may have other functions in non-neuronal cells.
ncbi gb acc num :
NM_014731.2
ncbi mol weight :
66,409 Da
uniprot summary :
PROSAPIP1: Belongs to the PROSAPIP1 family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Unknown function. Chromosomal Location of Human Ortholog: 20p13. Cellular Component: postsynaptic membrane; cytoskeleton; postsynaptic density; cytoplasm; cell junction