antibody

Slitrk1 Antibody

MBS150177

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

Antibody

Slitrk1 Antibody

Slitrk1

Slitrk1; TTM; LRRC12; KIAA1910; UNQ233/PRO266; SLIT and NTRK-like protein 1; Leucine-rich repeat-containing protein 12; SLIT and NTRK-like family, member 1

SLIT and NTRK-like protein 1; SLIT and NTRK-like protein 1; SLIT and NTRK-like protein 1; slit and trk like gene 1; leucine-rich repeat-containing protein 12; SLIT and NTRK-like family, member 1; Leucine-rich repeat-containing protein 12

SLITRK1

SLITRK1; SLITRK1; TTM; LRRC12; KIAA1910; LRRC12

SLIK1_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

696

This antibody is predicted to have no cross-reactivity to other Slitrk proteins.

Slitrk1 Antibody is affinity chromatography purified via peptide column.

Liquid

1 mg/mL

Slitrk1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Slitrk1 antibody can be used for detection of Slitrk1 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.

Conjugate: Unconjugated. Immunogen: Slitrk1 antibody was raised against a 18 amino acid synthetic peptide from near the center of human Slitrk1. Buffer: Slitrk1 Antibody is supplied in PBS containing 0.02% sodium azide.

Slitrk1 Antibody: SLIT and NTRK-like family 1 (Slitrk1) is a member a protein family consisting of six homologous transmembrane proteins (Slitrk1-6) that share two conserved leucine-rich repeat domains in the extracellular domain and have significant homology to Slit, a secreted axonal growth-controlling protein. These proteins are also homologous to trk neurotrophin receptors in their intracellular domains. Expression of Slitrk proteins is highly restricted to neural and brain tumor tissues, but varies within the family. For example, Slitrk1 is expressed primarily in mature neurons. Overexpression of Slitrk1 in transfected neuronal cells induced unipolar neurites, while expression of the other Slitrk proteins inhibited neurite outgrowth, suggesting that these proteins are involved in the control of neurite outgrowth. While Slitrk1 variants have been suggested associated with Tourette's Syndrome, it is thought to play only a minor role if at all.

40217817

NP_443142

NM_052910.2

Q96PX8

77,735 Da

This gene encodes a member of the SLITRK protein family. Members of this family are integral membrane proteins that are characterized by two N-terminal leucine-rich repeat (LRR) domains and a C-terminal region that shares homology with trk neurotrophin receptors. However, the protein encoded by this gene lacks the region of homology to neurotrophin receptors. This protein is thought to be involved in neurite outgrowth. Mutations in this gene may be associated with Tourette syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

0.1 mg

345 USD