TOCA-1 Antibody | MyBioSource MBS150174 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

TOCA-1 Antibody

catalog :

MBS150174

quantity :

0.1 mg

price :

345 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS150174

products type :

Antibody

products full name :

TOCA-1 Antibody

products short name :

TOCA-1

products name syn :

TOCA-1; TOCA1; C1orf39; TOCA1; Formin-binding protein 1-like; Transducer of Cdc42-dependent actin assembly protein 1; Toca-1; formin binding protein 1-like

other names :

formin-binding protein 1-like isoform 1; Formin-binding protein 1-like; formin-binding protein 1-like; toca-1; transducer of Cdc42-dependent actin assembly 1; transducer of Cdc42-dependent actin assembly protein 1; formin binding protein 1-like; Transducer of Cdc42-dependent actin assembly protein 1; Toca-1

products gene name :

FNBP1L

other gene names :

FNBP1L; FNBP1L; TOCA1; C1orf39; C1orf39; TOCA1; Toca-1

uniprot entry name :

FBP1L_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

551

purity :

TOCA-1 Antibody is affinity chromatography purified via peptide column.

form :

Liquid

concentration :

1 mg/mL

storage stability :

TOCA-1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

tested application :

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

app notes :

TOCA-1 antibody can be used for detection of TOCA-1 by Western blot at 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.

other info1 :

Conjugate: Unconjugated. Immunogen: TOCA-1 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of the human TOCA-1. Buffer: TOCA-1 Antibody is supplied in PBS containing 0.02% sodium azide.

products description :

TOCA-1 Antibody: Actin reorganization is important for the regulation of neuronal morphology. A protein involved in this process, the transducer of cdc42-dependent actin assembly 1 (TOCA-1) protein, a member of the evolutionarily conserved pombe CDC15 homology (PCH) protein family, is an essential component of the Cdc42 pathway. TOCA-1 binds both N-WASP and Cdc42 and is essential for Cdc42- and PIP2-induced actin polymerization, suggesting that TOCA-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex. Decreased expression of TOCA-1 significantly enhances neurite elongation in PC-12 cells; its overexpression in the same cells suppresses neurite elongation. It has been suggested that TOCA-1 negatively regulates axon branching by regulating membrane trafficking by regulating membrane trafficking through the F-BAR/EFC domain. Multiple isoforms of TOCA-1 are known to exist.

ncbi gi num :

68348709

ncbi acc num :

NP_001020119

ncbi gb acc num :

NM_001024948.2

uniprot acc num :

Q5T0N5

ncbi mol weight :

69,894 Da

ncbi summary :

The protein encoded by this gene binds to both CDC42 and N-WASP. This protein promotes CDC42-induced actin polymerization by activating the N-WASP-WIP complex and, therefore, is involved in a pathway that links cell surface signals to the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

uniprot summary :

FNBP1L: Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens. Belongs to the FNBP1 family. 5 isoforms of the human protein are produced by alternative splicing. Protein type: Adaptor/scaffold. Chromosomal Location of Human Ortholog: 1p22.1. Cellular Component: cytoskeleton; cytoplasmic membrane-bound vesicle; cytoplasm; plasma membrane; cell cortex. Molecular Function: protein binding; lipid binding. Biological Process: positive regulation of filopodium formation; vesicle transport along actin filament; vesicle organization and biogenesis; membrane invagination; cilium biogenesis; autophagy; membrane budding

size1 :

0.1 mg

price1 :

345 USD

more info or order :

MyBioSource product webpage