antibody

NGFR Antibody

MBS150167

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

human, mouse

western blot, ELISA, immunocytochemistry, enzyme immunoassay

Antibody

NGFR Antibody

NGFR

NGFR; CD271; p75NTR; TNFRSF16; p75(NTR); Gp80-LNGFR; Tumor necrosis factor receptor superfamily member 16; NGF receptor; nerve growth factor receptor (TNFR superfamily, member 16)

tumor necrosis factor receptor superfamily member 16; Tumor necrosis factor receptor superfamily member 16; tumor necrosis factor receptor superfamily member 16; p75 ICD; NGF receptor; TNFR superfamily, member 16; low affinity nerve growth factor receptor; low affinity neurotrophin receptor p75NTR; low-affinity nerve growth factor receptor; nerve growth factor receptor; Gp80-LNGFR; Low affinity neurotrophin receptor p75NTR; Low-affinity nerve growth factor receptor; NGF receptor; p75 ICD; CD_antigen: CD271

NGFR

NGFR; NGFR; CD271; p75NTR; TNFRSF16; p75(NTR); Gp80-LNGFR; TNFRSF16; NGF receptor

TNR16_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse

427

NGFR Antibody is affinity chromatography purified via peptide column.

Liquid

1 mg/mL

NGFR antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC)

NGFR antibody can be used for the detection of NGFR by Western blot at 1 mug/mL. Antibody can also be used for immunocytochemistry starting at 10 mug/mL.

Conjugate: Unconjugated. Immunogen: NGFR antibody was raised against purified recombinant human NGFR. Buffer: NGFR Antibody is supplied in PBS containing 0.02% sodium azide.

NGFR Antibody: The tumor necrosis factor (TNF) and TNF receptor (TNFR) gene superfamilies regulate numerous biological functions including cell proliferation, differentiation, and survival through regulating the activation of the transcription factor NF- B and various mitogen-activated protein kinases. Nerve growth factor receptor (NGFR) was one of the earliest characterized members of this family. Also known as the low-affinity receptor p75NTR, this receptor is involved in several diverse functions such as apoptosis, neurite outgrowth during development, and myelination. Its ligands include NGF, brain-derived neurotrophic factor (BDNF), NT3, and NT4. NGFR can also associate with other NGF receptors such as Trk through the cytosolic and transmembrane domains and thus can function as a co-receptor that refines Trk affinity and specificity for neurotrophins. Finally, upon binding of various neurotrophins, NGFR associates with tumor necrosis factor receptor-6 (TRAF6), suggesting that it can potentially function as a signal transducer for NGF signals through NGFR.

4505393

NP_002498

NM_002507.3

P08138

35,767 Da

Axonal Growth Inhibition (RHOA Activation) Pathway 106454!!Axonal Growth Stimulation Pathway 106453!!BDNF Signaling Pathway 712093!!Cell Death Signalling Via NRAGE, NRIF And NADE Pathway 106443!!Ceramide Signalling Pathway 106451!!Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!NADE Modulates Death Signalling Pathway 106446!!NF-kB Is Activated And Signals Survival Pathway 106450!!NFG And ProNGF Binds To P75NTR Pathway 106442

Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. [provided by RefSeq, Jul 2008]

0.1 mg

345 USD