antibody

GPAT1 Antibody

MBS150163

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

Antibody

GPAT1 Antibody

GPAT1

GPAT1; GPAT; GPAT1; KIAA1560; Glycerol-3-phosphate acyltransferase 1; mitochondrial; GPAT-1; glycerol-3-phosphate acyltransferase, mitochondrial

glycerol-3-phosphate acyltransferase 1, mitochondrial; Glycerol-3-phosphate acyltransferase 1, mitochondrial; glycerol-3-phosphate acyltransferase 1, mitochondrial; GPAT-1; glycerol 3-phosphate acyltransferase, mitochondrial; glycerol-3-phosphate acyltransferase, mitochondrial

GPAM

GPAM; GPAM; GPAT; GPAT1; GPAT1; KIAA1560; GPAT-1

GPAT1_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

828

GPAT1 Antibody is affinity chromatography purified via peptide column.

Liquid

1 mg/mL

GPAT1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

GPAT1 antibody can be used for detection of GPAT1 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.

Conjugate: Unconjugated. Immunogen: GPAT1 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of the human GPAT1. Buffer: GPAT1 Antibody is supplied in PBS containing 0.02% sodium azide.

GPAT1 Antibody: Glycerol-3-phosphate acyltransferase 1 (GPAT1), one of four known GPAT isoforms, is located on the mitochondrial outer membrane, allowing reciprocal regulation with carnitine palmitoyltransferase-1. It is thought to be critical for the development of hepatic steatosis; steatosis triggered by GPAT1 overexpression leads to hepatic and possibly peripheral insulin resistance. GPAT1 is transcriptionally upregulated by insulin and sterol regulatory element binding protein (SREBP-1) and downregulated by AMP-activated protein kinase. Mice deficient in GPAT1 exhibit decreased triacylglycerol (TAG) in cardiomyocytes even in high-fat diets, suggesting that GPAT1 contributes significantly to TAG accumulation in heart tissue during lipogenic or high fat diets. At least two isoforms of GPAT1 are known to exist.

190358539

NP_065969

NM_020918.5

Q9HCL2

93,795 Da

Activation Of Gene Expression By SREBF (SREBP) Pathway 685552!!CDP-diacylglycerol Biosynthesis Pathway 142255!!Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway 160977!!Glycerolipid Metabolism Pathway 82986!!Glycerolipid Metabolism Pathway 361!!Glycerophospholipid Biosynthesis Pathway 645313!!Glycerophospholipid Metabolism Pathway 82989!!Glycerophospholipid Metabolism Pathway 364!!Metabolic Pathways 132956!!Metabolism Pathway 477135

This gene encodes a mitochondrial enzyme which prefers saturated fatty acids as its substrate for the synthesis of glycerolipids. This metabolic pathway's first step is catalyzed by the encoded enzyme. Two forms for this enzyme exist, one in the mitochondria and one in the endoplasmic reticulum. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]

0.1 mg

345 USD