antibody

DcR1 Antibody

MBS150161

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

western blot, ELISA, immunocytochemistry, enzyme immunoassay

Antibody

DcR1 Antibody

DcR1

DcR1; LIT; DCR1; TRID; CD263; TRAILR3; TRAIL-R3; DCR1-TNFR; LIT; UNQ321/PRO366; Tumor necrosis factor receptor superfamily member 10C; Decoy TRAIL receptor without death domain; DcR1; tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain

Homo sapiens decoy receptor 1 (DcR1) mRNA, complete cds; Tumor necrosis factor receptor superfamily member 10C; tumor necrosis factor receptor superfamily member 10C; decoy receptor 1; cytotoxic TRAIL receptor-3; lymphocyte inhibitor of TRAIL; decoy TRAIL receptor without death domain; antagonist decoy receptor for TRAIL/Apo-2L; TNF-related apoptosis-inducing ligand receptor 3; tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain; Antagonist decoy receptor for TRAIL/Apo-2L; Decoy TRAIL receptor without death domain; Decoy receptor 1; DcR1; Lymphocyte inhibitor of TRAIL; TNF-related apoptosis-inducing ligand receptor 3; TRAIL receptor 3; TRAIL-R3; TRAIL receptor without an intracellular domain; CD_antigen: CD263

TNFRSF10C

TNFRSF10C; TNFRSF10C; LIT; DCR1; TRID; CD263; TRAILR3; TRAIL-R3; DCR1-TNFR; DCR1; LIT; TRAILR3; TRID; DcR1; TRAIL receptor 3; TRAIL-R3

TR10C_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

1180

DcR1 Antibody is affinity chromatography purified via peptide column.

Liquid

DcR1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

DcR1 antibody can be used for detection of DcR1 by Western blot 0.5 mug/mL. An approximate 65 kDa band can be detected. Antibody can also be used for immunocytochemistry starting at 10 mug/mL. For immunofluorescence start at 20 mug/mL.

Conjugate: Unconjugated. Immunogen: DcR1 antibody was raised against a peptide corresponding to amino acids in a extracellular domain of human DcR1 precursor. Buffer: DcR1 Antibody is supplied in PBS containing 0.02% sodium azide.

DcR1 Antibody: Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL. Two decoy receptors for TRAIL have been identified and designated DcR1/TRID/TRAIL-R3/LIT and DcR2/TRAIL-R4/TRUNDD. DcR1 has extracellular TRAIL-binding domain but lacks intracellular signaling domain. It is a glycophospholipid-anchored cell surface protein. DcR1 transcripts were expressed in many normal human tissues but not in most cancer cell lines. Overexpression of DcR1 did not induce apoptosis, but attenuated TRAIL-induced apoptosis.

2338421

AF012536

O14798

65 kDa

Apoptosis Pathway 83060!!Apoptosis Pathway 470!!Apoptosis Modulation And Signaling Pathway 198822!!Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!Direct P53 Effectors Pathway 137939!!Influenza A Pathway 217173!!Influenza A Pathway 217150!!Measles Pathway 213306!!Measles Pathway 213277

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL. [provided by RefSeq, Jul 2008]

0.1 mg

345 USD