ApoA4 Antibody | MyBioSource MBS150126 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

ApoA4 Antibody

catalog :

MBS150126

quantity :

0.1 mg

price :

345 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, chicken

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS150126

products type :

Antibody

products full name :

ApoA4 Antibody

products short name :

ApoA4

products name syn :

ApoA4; Apolipoprotein A-IV; Apolipoprotein A4; Apo-AIV; apolipoprotein A-IV

other names :

apolipoprotein A-IV; Apolipoprotein A-IV; apolipoprotein A-IV; apo-AIV; apoA-IV; apolipoprotein A4; apolipoprotein A-IV; Apolipoprotein A4

products gene name :

APOA4

other gene names :

APOA4; APOA4; Apo-AIV; ApoA-IV

uniprot entry name :

APOA4_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Chicken

sequence length :

396

purity :

ApoA4 Antibody is affinity chromatography purified via peptide column.

form :

Liquid

concentration :

1 mg/mL

storage stability :

ApoA4 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

tested application :

ELISA (EIA), Western Blot (WB)

app notes :

ApoA4 antibody can be used for detection of ApoA4 by Western blot at 1 mug/mL.

other info1 :

Conjugate: Unconjugated. Immunogen: ApoA4 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human ApoA4. Buffer: ApoA4 Antibody is supplied in PBS containing 0.02% sodium azide.

products description :

ApoA4 Antibody: Apolipoprotein A4 (also known as ApoA-IV) is a plasma protein that is an O-linked glycoprotein after proteolytic processing. ApoA4 is a major constituent of HDL and it also can be found on the surface of newly synthesized chylomicrons. The physiological function of ApoA4 is not completely identified so far, but evidence from several in vitro studies indicate that this apolipoprotein is involved in several steps of the reverse cholesterol transport pathway, which transports cholesterol from peripheral cells back to the liver.

ncbi gi num :

71773110

ncbi acc num :

AAA51744

ncbi gb acc num :

NM_000482.3

uniprot acc num :

P06727

ncbi mol weight :

45,399 Da

ncbi pathways :

Amyloids Pathway (366238); Chylomicron-mediated Lipid Transport Pathway (106157); Disease Pathway (530764); Diseases Associated With Visual Transduction Pathway (771581); Fat Digestion And Absorption Pathway (194385); Fat Digestion And Absorption Pathway (194324); Lipid Digestion, Mobilization, And Transport Pathway (106111); Lipoprotein Metabolism Pathway (106156); Metabolism Pathway (477135); Metabolism Of Lipids And Lipoproteins Pathway (160976)

ncbi summary :

Apoliprotein (apo) A-IV gene contains 3 exons separated by two introns. A sequence polymorphism has been identified in the 3'UTR of the third exon. The primary translation product is a 396-residue preprotein which after proteolytic processing is secreted its primary site of synthesis, the intestine, in association with chylomicron particles. Although its precise function is not known, apo A-IV is a potent activator of lecithin-cholesterol acyltransferase in vitro. [provided by RefSeq, Jul 2008]

uniprot summary :

APOA4: May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons. Synthesized primarily in the intestine and secreted in plasma. Belongs to the apolipoprotein A1/A4/E family. Protein type: Endoplasmic reticulum; Cell adhesion; Secreted, signal peptide; Secreted; Lipid-binding. Chromosomal Location of Human Ortholog: 11q23. Cellular Component: extracellular space; chylomicron; cell surface; endoplasmic reticulum lumen; early endosome; extracellular region; cytosol. Molecular Function: lipid transporter activity; antioxidant activity; protein binding; protein homodimerization activity; copper ion binding; cholesterol transporter activity; cholesterol binding; phosphatidylcholine binding; lipid binding. Biological Process: cholesterol metabolic process; phototransduction, visible light; positive regulation of fatty acid biosynthetic process; multicellular organismal lipid catabolic process; removal of superoxide radicals; lipid homeostasis; neurite regeneration; protein-lipid complex assembly; cholesterol efflux; lipoprotein metabolic process; lipid transport; cholesterol biosynthetic process; phosphatidylcholine metabolic process; cholesterol homeostasis; leukocyte adhesion; reverse cholesterol transport; phospholipid efflux; innate immune response in mucosa; regulation of cholesterol absorption; hydrogen peroxide catabolic process; response to lipid hydroperoxide; positive regulation of lipoprotein lipase activity; retinoid metabolic process; regulation of cholesterol transport

size1 :

0.1 mg

price1 :

345 USD

more info or order :

MyBioSource product webpage