antibody

OMI Antibody

MBS150111

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

Antibody

OMI Antibody

OMI

OMI; OMI; PARK13; PRSS25; OMI; Serine protease HTRA2; mitochondrial; High temperature requirement protein A2; HtrA2; HtrA serine peptidase 2

serine protease; Serine protease HTRA2, mitochondrial; serine protease HTRA2, mitochondrial; serine protease 25; protease, serine, 25; serine proteinase OMI; HtrA-like serine protease; Omi stress-regulated endoprotease; high temperature requirement protein A2; HtrA serine peptidase 2; High temperature requirement protein A2; HtrA2; Omi stress-regulated endoprotease; Serine protease 25; Serine proteinase OMI

HTRA2

HTRA2; HTRA2; OMI; PARK13; PRSS25; OMI; PRSS25; HtrA2

HTRA2_HUMAN

Polyclonal

IgG

Rabbit

Human

458

OMI Antibody is Ion exchange chromatography purified.

Liquid

1 mg/mL

OMI antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

OMI antibody can be used for detection of OMI by Western blot at 0.5 to 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 10 mug/mL. For immunofluorescence start at 20 mug/mL.

Conjugate: Unconjugated. Immunogen: OMI antibody was raised against a peptide corresponding to 15 amino acids near the C-terminus of human OMI. Buffer: OMI Antibody is supplied in PBS containing 0.02% sodium azide.

OMI Antibody: Inhibitor of apoptosis proteins (IAPs) were initially identified in baculoviruses as proteins that inhibit apoptosis of the host cells to allow time for viral replication. Cellular homologues containing at least one baculoviral IAP repeat (BIR) motif essential for their anti-apoptosis activity have been identified in yeasts and higher organisms and often act by binding and inhibiting processed caspases. The activity of these proteins can be modulated by the expression of proteins such as Smac/DIABLO and XAF-1 which displace or prevent the binding of caspases by IAPs. Recently, a mitochondrial serine protease termed Omi/HtrA2 has been found to bind IAPs. Similar to Smac, Omi possesses a conserved IAP-binding motif, but acts to cleave IAPs to irreversibly inactivate IAPs and promote apoptosis.

5870865

AAB94569

O43464

39,914 Da

Apoptosis Modulation And Signaling Pathway 198822!!Parkinson's Disease Pathway 83098!!Parkinsons Disease Pathway 705377

This gene encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts with an alternatively spliced form of mitogen-activated protein kinase 14. The protein has also been localized to the mitochondria with release to the cytosol following apoptotic stimulus. The protein is thought to induce apoptosis by binding the apoptosis inhibitory protein baculoviral IAP repeat-containing 4. Nuclear localization of this protein has also been observed. Alternate splicing of this gene results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined. [provided by RefSeq, Jul 2008]

0.1 mg

345 USD