antibody

DDX3 Antibody

MBS150105

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

human, mouse

western blot, ELISA, immunocytochemistry, enzyme immunoassay

Antibody

DDX3 Antibody

DDX3

DDX3; DBX; DDX3; HLP2; DDX14; DBX; ATP-dependent RNA helicase DDX3X; DEAD box protein 3; X-chromosomal; DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked

DEAD box RNA helicase DDX3; ATP-dependent RNA helicase DDX3X; ATP-dependent RNA helicase DDX3X; DEAD/H box-3; DEAD box, X isoform; helicase-like protein 2; DEAD box protein 3, X-chromosomal; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3; DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked; DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked; DEAD box protein 3, X-chromosomal; DEAD box, X isoform; Helicase-like protein 2; HLP2

DDX3X

DDX3X; DDX3X; DBX; DDX3; HLP2; DDX14; CAP-Rf; DBX; DDX3; HLP2

DDX3X_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

662

DDX3 antibody will detect both DDX3 and DBY.

DDX3 Antibody is affinity chromatography purified via peptide column.

Liquid

1 mg/mL

DDX3 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC)

DDX3 antibody can be used for the detection of DDX3 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunocytochemistry starting at 10 mug/mL.

Conjugate: Unconjugated. Immunogen: DDX3 antibody was raised against a 16 amino acid synthetic peptide from near the center of human DDX3. Buffer: DDX3 Antibody is supplied in PBS containing 0.02% sodium azide.

DDX3 Antibody: DDX3 contains all of the motifs of the DEAD-box family of RNA helicases, including the Asp-Glu-Ala-Asp sequence that gives the protein family its name and distinguishes it from other RNA helicases. DDX3 is localized to the X chromosome and has a highly conserved functional homolog (DBY) on the Y chromosome. DDX3 is thought to be involved in RNA splicing, RNA transport, and translation initiation. It has also been shown to be involved in cell growth control and is deregulated in hepatitis virus-associated hepatocellular carcinoma. Recent experiments suppressing DDX3 expression blocked HIV-1 RNA export from the nucleus, suggesting that DDX3 functions as a shuttling protein that transports the HIV-1 protein Rev and its cofactor CRM1 from the nucleus to the cytoplasm.

3523150

AAC34298

O00571

71,355 Da

Hepatitis B Pathway 694606!!RIG-I-like Receptor Signaling Pathway 117292!!RIG-I-like Receptor Signaling Pathway 116128!!TNF-alpha/NF-kB Signaling Pathway 198884!!Viral Carcinogenesis Pathway 658418!!Viral Carcinogenesis Pathway 662842

The protein encoded by this gene is a member of the large DEAD-box protein family, that is defined by the presence of the conserved Asp-Glu-Ala-Asp (DEAD) motif, and has ATP-dependent RNA helicase activity. This protein has been reported to display a high level of RNA-independent ATPase activity, and unlike most DEAD-box helicases, the ATPase activity is thought to be stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. This gene has a paralog located in the nonrecombining region of the Y chromosome. Pseudogenes sharing similarity to both this gene and the DDX3Y paralog are found on chromosome 4 and the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

0.1 mg

345 USD