antibody

Dact3 Antibody

MBS150088

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, ELISA, enzyme immunoassay

Antibody

Dact3 Antibody

Dact3

Dact3; RRR1; DAPPER3; RRR1; Dapper homolog 3; Antagonist of beta-catenin Dapper homolog 3; dapper, antagonist of beta-catenin, homolog 3 (Xenopus laevis)

Dapper homolog 3; Dapper homolog 3; dapper homolog 3; arginine-rich region 1 protein; antagonist of beta-catenin Dapper homolog 3; dapper, antagonist of beta-catenin, homolog 3; dishevelled-binding antagonist of beta-catenin 3; Antagonist of beta-catenin Dapper homolog 3; Arginine-rich region 1 protein; Dapper antagonist of catenin 3

DACT3

DACT3; DACT3; RRR1; DAPPER3; RRR1

DACT3_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

629

Dact3 Antibody is affinity chromatography purified via peptide column.

Liquid

1 mg/mL

Dact3 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB)

Dact3 antibody can be used for detection of Dact3 by Western blot at 1 mug/mL.

Conjugate: Unconjugated. Immunogen: Dact3 antibody was raised against a 17 amino acid synthetic peptide from near the amino terminus of human Dact3. Buffer: Dact3 Antibody is supplied in PBS containing 0.02% sodium azide.

Dact3 Antibody: The Wnt signaling cascade is a conserved process in multicellular animals that plays important roles during development and can contribute to cancer and other diseases. Many members of this pathway are also expressed in the postnatal tissues such as brain. One such protein is Dact3, a member of the Dact protein family that was initially identified through binding to Disheveled (Dvl), a cytoplasmic protein essential to Wnt signaling. Dact3 is expressed in the ventral region of maturing somites, limb bud and branchial arch mesenchyme, embryonic CNS, and the adult brain. Recent evidence shows that Dact3 acts as a negative regulator Wnt/beta-catenin signaling that is repressed at the transcriptional level in colorectal cancer and this repression is associated with bivalent histone modifications. This repression can be reversed by pharmacological agents that targets both histone methylation and deacetylation, suggesting that Dact3 may be a potential target for therapeutic treatment of this cancer. At least three isoforms of Dact3 are known to exist.

119368655

Q96B18.2

Q96B18

64,949 Da

DACT3: May be involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. Belongs to the dapper family. Protein type: Unknown function. Chromosomal Location of Human Ortholog: 19q13.32. Cellular Component: cytoplasm. Molecular Function: identical protein binding; protein kinase C binding; protein kinase A binding. Biological Process: Wnt receptor signaling pathway; negative regulation of Wnt receptor signaling pathway; negative regulation of cell growth

0.1 mg

345 USD