KAI1 Antibody | MyBioSource MBS150073 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

KAI1 Antibody

catalog :

MBS150073

quantity :

0.1 mg

price :

345 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS150073

products type :

Antibody

products full name :

KAI1 Antibody

products short name :

KAI1

products name syn :

KAI1; R2; 4F9; C33; IA4; ST6; GR15; KAI1; SAR2; TSPAN27; CD82 antigen; C33 antigen; Tspan-27; CD82 molecule

other names :

CD82 antigen isoform 1; CD82 antigen; CD82 antigen; tspan-27; C33 antigen; tetraspanin-27; inducible membrane protein R2; metastasis suppressor Kangai-1; kangai 1 (suppression of tumorigenicity 6, prostate; CD82 antigen (R2 leukocyte antigen, antigen detected by monoclonal and antibody IA4)); CD82 molecule; C33 antigen; IA4; Inducible membrane protein R2; Metastasis suppressor Kangai-1; Suppressor of tumorigenicity 6 protein; Tetraspanin-27; Tspan-27; CD_antigen: CD82

products gene name :

CD82

other gene names :

CD82; CD82; R2; 4F9; C33; IA4; ST6; GR15; KAI1; SAR2; TSPAN27; KAI1; SAR2; ST6; TSPAN27; Tspan-27

uniprot entry name :

CD82_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

267

purity :

KAI1 Antibody is affinity chromatography purified via peptide column.

form :

Liquid

concentration :

1 mg/mL

storage stability :

KAI1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

tested application :

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

app notes :

KAI1 antibody can be used for detection of KAI1 by Western blot at 0.5 - 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.

other info1 :

Conjugate: Unconjugated. Immunogen: KAI1 antibody was raised against a 15 amino acid synthetic peptide from near the carboxy terminus of human KAI1. Buffer: KAI1 Antibody is supplied in PBS containing 0.02% sodium azide.

products description :

KAI1 Antibody: KAI1 was initially identified from a T-cell activation study as a four-transmembrane protein that plays an accessory role in T-cell activation, and was later determined to act as a cancer metastasis suppressor gene. This protein is ubiquitously expressed at moderate to high levels in most tissues, but its expression is downregulated during tumor progression. The loss of KAI1 and p53 is associated with poor survival for prostate and other cancer patients. Recently, KAI1 was found to interact with DARC, the Duffy antigen for chemokines using a yeast two hybrid screen. It is thought that tumor cells dislodged from the primary tumor and expressing KAI1 interact with DARC proteins expressed on vascular cells, transmitting a senescent signal to the tumor cells, while tumor cells that have lost KAI1 expression can proliferate and potentially give rise to metastases. At least two isoforms of KAI1 are known to exist.

ncbi gi num :

4504813

ncbi acc num :

NP_002222

ncbi gb acc num :

NM_002231.3

uniprot acc num :

P27701

ncbi mol weight :

26,818 Da

ncbi pathways :

Direct P53 Effectors Pathway (137939); Integrated Pancreatic Cancer Pathway (711360); P53 Signaling Pathway (83055); P53 Signaling Pathway (465)

ncbi summary :

This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

CD82: a widespread transmembrane protein of the tetraspanin family. A metastasis-suppressor whose decreased expression may be involved in malignant progression. Suppresses tumor metastasis of many cancers including cancers of the prostate, bladder, colon, cervix, liver, and lung (NSCLC). It is a target of estrogen receptor-mediated gene repression and is downregulated in primary human breast cancer. May be a prognostic marker for lung cancer and tumor metastatic potential. Interacts with cell surface proteins including integrins, cadherins, CD4, CD8, IGSF8. Modulates EGFR signaling. May suppress invasion by inhibiting integrin-dependent crosstalk with c-Met receptor and Src kinases. Its regulation of c-Met signaling apparently affects cancer cell migration. Protein type: Cell surface; Membrane protein, multi-pass; Membrane protein, integral. Chromosomal Location of Human Ortholog: 11p11.2. Cellular Component: integral to plasma membrane; plasma membrane. Molecular Function: protein binding. Disease: Prostate Cancer

size1 :

0.1 mg

price1 :

345 USD

more info or order :

MyBioSource product webpage