antibody

BANP Antibody

MBS150064

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

Antibody

BANP Antibody

BANP

BANP; BEND1; SMAR1; SMARBP1; BEND1; Protein BANP; BEN domain-containing protein 1; BTG3 associated nuclear protein

protein BANP isoform g; Protein BANP; protein BANP; BEN domain-containing protein 1; scaffold/matrix-associated region-1-binding protein; BTG3 associated nuclear protein; BEN domain-containing protein 1; Btg3-associated nuclear protein; Scaffold/matrix-associated region-1-binding protein

BANP

BANP; BANP; BEND1; SMAR1; SMARBP1; BEND1; SMAR1

BANP_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

519

BANP Antibody is affinity chromatography purified via peptide column.

Liquid

1 mg/mL

BANP antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

BANP antibody can be used for detection of BANP by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 10 mug/mL. For immunofluorescence start at 20 mug/mL.

Conjugate: Unconjugated. Immunogen: BANP antibody was raised against a 14 amino acid synthetic peptide near the center of human BANP. Buffer: BANP Antibody is supplied in PBS containing 0.02% sodium azide.

BANP Antibody: BANP was initially identified as a binding protein to BTG3 in a yeast two-hybrid screen. BANP acts as a tumor suppressor by stabilizing p53 expression and leading to cell cycle arrest. p53 in turn binds to upstream elements of the BANP promoter, thereby forming a feedback loop. BANP is down-regulated in advanced stages of human breast cancer, and its overexpression in breast cancer cell lines inhibits their ability to metastasize by modulating TGF-beta signaling. Furthermore, BANP can modulate NF- B transactivation and can inhibit tumorigenesis by regulating NF- B target genes. Recent experiments have shown that BANP can also repress HIV-1 LTR mediated transcription by tethering the LTR matrix attachment region to nuclear matrix.

291084803

NP_001167014

NM_001173543.1

Q8N9N5

55,502 Da

This gene encodes a protein that binds to matrix attachment regions. The protein forms a complex with p53 and negatively regulates p53 transcription, and functions as a tumor suppressor and cell cycle regulator. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

BANP: Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 Ser-15 phosphorylation and nuclear accumulation, which causes cell cycle arrest. Belongs to the BANP/SMAR1 family. 6 isoforms of the human protein are produced by alternative splicing. Protein type: Tumor suppressor. Chromosomal Location of Human Ortholog: 16q24. Cellular Component: nucleoplasm. Molecular Function: protein binding; DNA binding; p53 binding. Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent; multicellular organismal development; chromatin modification; negative regulation of protein catabolic process; cell cycle

0.1 mg

345 USD