catalog number :
MBS150061
products full name :
ZBTB8 Antibody
products short name :
ZBTB8
products name syn :
ZBTB8; BOZF1; ZBTB8; ZNF916A; BOZF1; Zinc finger and BTB domain-containing protein 8A; BOZ-F1; zinc finger and BTB domain containing 8
other names :
zinc finger and BTB domain-containing protein 8A; Zinc finger and BTB domain-containing protein 8A; zinc finger and BTB domain-containing protein 8A; zinc finger and BTB domain containing 8; BTB/POZ and zinc-finger domain-containing factor; BTB/POZ and zinc-finger domains factor on chromosome 1; zinc finger and BTB domain containing 8A; BTB/POZ and zinc-finger domain-containing factor; BTB/POZ and zinc-finger domains factor on chromosome 1; BOZ-F1
products gene name :
ZBTB8A
other gene names :
ZBTB8A; ZBTB8A; BOZF1; ZBTB8; ZNF916A; BOZF1; BOZ-F1
uniprot entry name :
ZBT8A_HUMAN
reactivity :
Human, Mouse
specificity :
At least two isoforms of ZBTB8 are known to exist; this antibody will recognize both isoforms. This antibody is predicted to not cross-react with other ZBTB protein family members.
purity :
ZBTB8 Antibody is affinity chromatography purified via peptide column.
storage stability :
ZBTB8 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
tested application :
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
app notes :
ZBTB8 antibody can be used for detection of ZBTB8 by Western blot at 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 5 mug/mL.
other info1 :
Conjugate: Unconjugated. Immunogen: ZBTB8 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human ZBTB8. Buffer: ZBTB8 Antibody is supplied in PBS containing 0.02% sodium azide.
products description :
ZBTB8 Antibody: The ZBTB family of proteins is comprised of diverse zinc finger proteins that also contain a BTB (BR-C, ttk and bab) domain. ZBTB8, also known as BOZ-F1, is present in multiple tissues, and is highly expressed in the cytoplasm of the placenta. While little is known about ZBTB8, other ZBTB proteins, such as ZBTB4 bind methylated DNA and repress transcription. Another ZBTB proteins, ZBTB7A, has been implicated as a proto-oncogene whose overexpression contributes to malignancy in breast cancer, suggesting that ZBTB8 may act as a transcriptional repressor or be involved in tumorigenesis.
ncbi gb acc num :
NM_001040441.1
ncbi mol weight :
38,344 Da
uniprot summary :
ZBTB8: May be involved in transcriptional regulation. 2 isoforms of the human protein are produced by alternative splicing. Protein type: C2H2-type zinc finger protein. Chromosomal Location of Human Ortholog: 1p35.1. Cellular Component: nucleus. Molecular Function: DNA binding; metal ion binding. Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent