AXIN2 Antibody | MyBioSource MBS150049 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

AXIN2 Antibody

catalog :

MBS150049

quantity :

0.1 mg

price :

345 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS150049

products type :

Antibody

products full name :

AXIN2 Antibody

products short name :

AXIN2

products name syn :

AXIN2; AXIL; ODCRCS; Axin-2; Axin-like protein; Axil; axin 2

other names :

axin-2; Axin-2; axin-2; conductin; axin-like protein; axis inhibition protein 2; axin 2; Axin-like protein; Axil; Axis inhibition protein 2; Conductin

products gene name :

AXIN2

other gene names :

AXIN2; AXIN2; AXIL; ODCRCS; Axil

uniprot entry name :

AXIN2_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

843

specificity :

AXIN2 antibody is predicted to not cross-react with AXIN1. At least four isoforms of AXIN2 are known to exist; this antibody will recognize all four.

purity :

AXIN2 Antibody is affinity chromatography purified via peptide column.

form :

Liquid

concentration :

1 mg/mL

storage stability :

AXIN2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

tested application :

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

app notes :

AXIN2 antibody can be used for detection of AXIN2 by Western blot at 1 ug/mL. Antibody can also be used for immunohistochemistry starting at 5 ug/mL. For immunofluorescence start at 20 ug/mL. Optimal dilutions for each application to be detemined by the researcher. Positive Control: MBS151736 Mouse Lung Tissue Lysate

other info1 :

Conjugate: Unconjugated. Immunogen: AXIN2 antibody was raised against a 20 amino acid synthetic peptide near the carboxy terminus of human AXIN2. Buffer: AXIN2 Antibody is supplied in PBS containing 0.02% sodium azide.

other info2 :

Acession Number: AAF22799

products description :

AXIN2 Antibody: Like the related protein AXIN1, AXIN2 is thought to play an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway. In mouse, AXIN2 organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and AXIN2, which leads to the degradation of beta-catenin, which is thought to be an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.

ncbi gi num :

195927059

ncbi acc num :

AAF22799

ncbi gb acc num :

NM_004655.3

uniprot acc num :

Q9Y2T1

ncbi mol weight :

85; 93 kDa

ncbi pathways :

Basal Cell Carcinoma Pathway (83113); Basal Cell Carcinoma Pathway (525); Canonical Wnt Signaling Pathway (138032); Colorectal Cancer Pathway (83106); Colorectal Cancer Pathway (518); Disease Pathway (530764); Endometrial Cancer Pathway (83109); Endometrial Cancer Pathway (521); Hippo Signaling Pathway (749777); Hippo Signaling Pathway (750388)

ncbi summary :

The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008]

uniprot summary :

axin 2: is a negative regulator of the Wnt pathway, which is critical in stem cell signaling, morphogenesis, the mesenchymal-epithelial transition, and many cancers. Axin functions as a tumor suppressor. Probably facilitates the phosphorylation of beta-catenin and APC by GSK3B, leading to their ubiquitination and subsequent proteolysis. Is downregulated during progression of esophageal squamous cell carcinoma. Axin1/2 mediate cross-talk between TGF-beta and Wnt signaling pathways. Protein type: Adaptor/scaffold. Chromosomal Location of Human Ortholog: 17q24.1. Cellular Component: Golgi apparatus; centrosome; cytoplasmic membrane-bound vesicle; postsynaptic density; cell cortex; cytosol; beta-catenin destruction complex; nucleoplasm; microtubule cytoskeleton; cytoplasmic microtubule; cytoplasm; plasma membrane; nucleus. Molecular Function: protein binding; enzyme binding; ubiquitin protein ligase binding; beta-catenin binding; protein kinase binding; GTPase activator activity. Biological Process: odontogenesis; cell proliferation; negative regulation of cell proliferation; intramembranous ossification; regulation of mismatch repair; mRNA stabilization; negative regulation of osteoblast differentiation; dorsal/ventral axis specification; positive regulation of protein amino acid phosphorylation; maintenance of DNA repeat elements; bone mineralization; positive regulation of GTPase activity. Disease: Oligodontia-colorectal Cancer Syndrome

size1 :

0.1 mg

price1 :

345 USD

more info or order :

MyBioSource product webpage