antibody

Bim Antibody [1C2H4]

MBS150042

0.1 mg

345 USD

monoclonal

mouse

nonconjugated

1C2H4

human, mouse, rat

western blot, ELISA, immunocytochemistry, enzyme immunoassay

Antibody

Bim Antibody [1C2H4]

Bim

Bim Antibody [1C2H4] : BAM; BIM; BOD; BCL2-like 11 (apoptosis facilitator)

bcl-2-like protein 11 isoform 1; Bcl-2-like protein 11; bcl-2-like protein 11; bcl-2 interacting protein Bim; bcl-2-related ovarian death agonist; bcl-2 interacting mediator of cell death; BCL2-like 11 (apoptosis facilitator); Bcl2-interacting mediator of cell death

BCL2L11

BCL2L11; BCL2L11; BAM; BIM; BOD; BIM; Bcl2-L-11

B2L11_HUMAN

Monoclonal

IgG1

1C2H4

Mouse

Human, Mouse, Rat

198

Bim Monoclonal Antibody is immunoaffinity chromotography purified IgG.

Liquid

1 mg/mL

Bim monoclonal antibody can be stored at -20 degree C, stable for one year.

ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

Bim antibody can be used for detection of Bim by Western blot at 1 mug/mL. Antibody can also be used for immunocytochemistry starting at 10 mug/mL. For immunofluorescence start at 20 mug/mL.

Conjugate: Unconjugated. Immunogen: Mouse monoclonal Bim antibody was raised against a recombinant protein corresponding to amino acids 2 to 198 of human Bim. Buffer: Bim Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.

Bim Monoclonal Antibody: Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, and Hrk, form a growing subclass of the Bcl-2 family. Bim is another BH3 domain containing protein which can induce apoptosis. Bim interacts with diverse members in the pro-survival Bcl-2 sub-family including Bcl-2, Bcl-xL and Bcl-w. The messenger RNA of Bim is ubiquitously expressed in multiple tissues and cell lines.

20336315

NP_619527

NM_138621.4

O43521

8,523 Da

Activation Of BH3-only Proteins Pathway 105658!!Activation Of BIM And Translocation To Mitochondria Pathway 105662!!Apoptosis Pathway 198797!!Apoptosis Pathway 105648!!Apoptosis Modulation And Signaling Pathway 198822!!B Cell Receptor Signaling Pathway 198909!!BDNF Signaling Pathway 712093!!BH3-only Proteins Associate With And Inactivate Anti-apoptotic BCL-2 Members Pathway 105664!!Cell Death Signalling Via NRAGE, NRIF And NADE Pathway 106443!!DNA Damage Response (only ATM Dependent) Pathway 198827

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2013]

0.1 mg

345 USD