ORAI1 Antibody [6D11A11] | MyBioSource MBS150032 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

ORAI1 Antibody [6D11A11]

catalog :

MBS150032

quantity :

0.1 mg

price :

345 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

6D11A11

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS150032

products type :

Antibody

products full name :

ORAI1 Antibody [6D11A11]

products short name :

ORAI1

products name syn :

ORAI1 Antibody [6D11A11] : IMD9; ORAT1; CRACM1; TMEM142A; ORAI calcium release-activated calcium modulator 1

other names :

Calcium release-activated calcium channel protein 1; Calcium release-activated calcium channel protein 1; calcium release-activated calcium channel protein 1; protein orai-1; transmembrane protein 142A; calcium release-activated calcium modulator 1; ORAI calcium release-activated calcium modulator 1; Protein orai-1; Transmembrane protein 142A

products gene name :

ORAI1

other gene names :

ORAI1; ORAI1; IMD9; TAM2; ORAT1; CRACM1; TMEM142A; CRACM1; TMEM142A

uniprot entry name :

CRCM1_HUMAN

clonality :

Monoclonal

isotype :

IgG2b

clone :

6D11A11

host :

Mouse

reactivity :

Human, Mouse, Rat

sequence length :

301

purity :

ORAI1 Monoclonal Antibody is immunoaffinity chromotography purified IgG.

form :

Liquid

concentration :

1 mg/mL

storage stability :

ORAI1 monoclonal antibody can be stored at -20 degree C, stable for one year.

tested application :

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

app notes :

ORAI1 antibody can be used for detection of ORAI1 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.

other info1 :

Conjugate: Unconjugated. Immunogen: Mouse monoclonal ORAI1 antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human ORAI1. Buffer: ORAI1 Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.

products description :

ORAI1 Monoclonal Antibody: Antigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. ORAI1 is a recently identified four-transmembrane spanning protein that is an essential component of CRAC. A missense mutation in this protein in humans is the cause of one fo rm of hereditary severe combined immune deficiency (SCID) which results in ablated T-cell Ca++ entry. It has been suggested that ORAI1 functions as a highly selective Ca++ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor. ORAI1 often migrates at a higher than expected molecular weight in SDS-PAGE. This antibody is predicted to have no cross-reactivity to ORAI2 or ORAI3.

ncbi gi num :

97180269

ncbi acc num :

Q96D31.2

uniprot acc num :

Q96D31

ncbi mol weight :

25,337 Da

ncbi pathways :

Adaptive Immune System Pathway (366160); Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway (576249); Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Elevation Of Cytosolic Ca2+ Levels Pathway (106047); Hemostasis Pathway (106028); Immune System Pathway (106386); Platelet Activation Pathway (952858); Platelet Calcium Homeostasis Pathway (187202); Platelet Homeostasis Pathway (187198)

ncbi summary :

The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1). [provided by RefSeq, Sep 2011]

uniprot summary :

ORAI1: Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1. CRAC channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT. Interacts with STIM1 and STIM2. Interacts with EFCAB4B/CRACR2A; the interaction is direct and takes place in absence of Ca(2+). Forms a complex with EFCAB4B/CRACR2A and STIM1 at low concentration of Ca(2+), the complex dissociates at elevated Ca(2+) concentrations. Belongs to the Orai family. Protein type: Membrane protein, integral; Membrane protein, multi-pass; Channel, calcium. Chromosomal Location of Human Ortholog: 12q24.31. Cellular Component: protein complex; membrane; integral to plasma membrane. Molecular Function: calmodulin binding; identical protein binding; protein binding; store-operated calcium channel activity. Biological Process: immune system process; regulation of calcium ion transport; positive regulation of calcium ion transport; blood coagulation. Disease: Myopathy, Tubular Aggregate, 2; Immunodeficiency 9

size1 :

0.1 mg

price1 :

345 USD

more info or order :

MyBioSource product webpage