antibody

MD-2 Antibody [9F1B1]

MBS150024

0.1 mg

345 USD

monoclonal

mouse

nonconjugated

9F1B1

human, mouse

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

Antibody

MD-2 Antibody [9F1B1]

MD-2

MD-2 Antibody [9F1B1] : MD2; MD-2; ly-96; ESOP-1; lymphocyte antigen 96

lymphocyte antigen 96; Lymphocyte antigen 96; lymphocyte antigen 96; protein MD-2; myeloid differentiation protein-2; lymphocyte antigen 96; ESOP-1; Protein MD-2

LY96

LY96; LY96; MD2; MD-2; ly-96; ESOP-1; ESOP1; MD2; Ly-96

LY96_HUMAN

Monoclonal

IgG1

9F1B1

Mouse

Human, Mouse

160

MD-2 Monoclonal Antibody is immunoaffinity chromotography purified IgG.

Liquid

1 mg/mL

MD-2 monoclonal antibody can be stored at -20 degree C, stable for one year.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

MD-2 antibody can be used for detection of MD-2 by Western blot at 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.

Conjugate: Unconjugated. Immunogen: Mouse monoclonal MD-2 antibody was raised against a recombinant protein corresponding to amino acids 2 to 160 of human MD-2. Buffer: MD-2 Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.

MD-2 Monoclonal Antibody: MD-2 is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses. TLR4, the major signaling receptor for lipopolysaccharide (LPS), requires the binding of MD-2 to its extracellular region for maximal response to LPS. The specificity of this response is determined by the species of MD-2; e.g., human MD-2 transfected into mouse cells can cause mouse TLR4 to react to LPS analogs that are normally antagonistic to human but not mouse TLR4.

223555998

NP_056179

NM_015364.3

Q9Y6Y9

14,933 Da

Activated TLR4 Signalling Pathway 106400!!Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway 187088!!IKK Complex Recruitment Mediated By RIP1 Pathway 187090!!Immune System Pathway 106386!!Innate Immune System Pathway 106387!!MyD88-independent Cascade Pathway 106401!!MyD88:Mal Cascade Initiated On Plasma Membrane Pathway 106390!!NF-kappa B Signaling Pathway 634527!!Pathogenic Escherichia Coli Infection Pathway 83103!!Pathogenic Escherichia Coli Infection Pathway 672459

This gene encodes a protein which associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccyaride (LPS), thus providing a link between the receptor and LPS signaling. Studies of the mouse ortholog suggest that this gene may be involved in endotoxin neutralization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2010]

0.1 mg

345 USD