MD-2 Antibody [1A2E3] | MyBioSource MBS150022 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

MD-2 Antibody [1A2E3]

catalog :

MBS150022

quantity :

0.1 mg

price :

345 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1A2E3

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS150022

products type :

Antibody

products full name :

MD-2 Antibody [1A2E3]

products short name :

MD-2

products name syn :

MD-2 Antibody [1A2E3] : MD2; MD-2; ly-96; ESOP-1; lymphocyte antigen 96

other names :

lymphocyte antigen 96; Lymphocyte antigen 96; lymphocyte antigen 96; protein MD-2; myeloid differentiation protein-2; lymphocyte antigen 96; ESOP-1; Protein MD-2

products gene name :

LY96

other gene names :

LY96; LY96; MD2; MD-2; ly-96; ESOP-1; ESOP1; MD2; Ly-96

uniprot entry name :

LY96_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

1A2E3

host :

Mouse

reactivity :

Human, Mouse, Rat

sequence length :

160

purity :

MD-2 Monoclonal Antibody is immunoaffinity chromotography purified IgG.

form :

Liquid

concentration :

1 mg/mL

storage stability :

MD-2 monoclonal antibody can be stored at -20 degree C, stable for one year.

tested application :

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

app notes :

MD-2 antibody can be used for detection of MD-2 by Western blot at 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL.

other info1 :

Conjugate: Unconjugated. Immunogen: Mouse monoclonal MD-2 antibody was raised against a recombinant protein corresponding to amino acids 2 to 160 of human MD-2. Buffer: MD-2 Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.

products description :

MD-2 Monoclonal Antibody: MD-2 is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses. TLR4, the major signaling receptor for lipopolysaccharide (LPS), requires the binding of MD-2 to its extracellular region for maximal response to LPS. The specificity of this response is determined by the species of MD-2; e.g., human MD-2 transfected into mouse cells can cause mouse TLR4 to react to LPS analogs that are normally antagonistic to human but not mouse TLR4.

ncbi gi num :

223555998

ncbi acc num :

NP_056179

ncbi gb acc num :

NM_015364.3

uniprot acc num :

Q9Y6Y9

ncbi mol weight :

14,933 Da

ncbi pathways :

Activated TLR4 Signalling Pathway (106400); Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway (187088); IKK Complex Recruitment Mediated By RIP1 Pathway (187090); Immune System Pathway (106386); Innate Immune System Pathway (106387); MyD88-independent Cascade Pathway (106401); MyD88:Mal Cascade Initiated On Plasma Membrane Pathway (106390); NF-kappa B Signaling Pathway (634527); Pathogenic Escherichia Coli Infection Pathway (83103); Pathogenic Escherichia Coli Infection Pathway (672459)

ncbi summary :

This gene encodes a protein which associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccyaride (LPS), thus providing a link between the receptor and LPS signaling. Studies of the mouse ortholog suggest that this gene may be involved in endotoxin neutralization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2010]

uniprot summary :

LY96: a secreted protein that binds to the extracellular domains of TLR2 and TLR4. Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. Enhances TLR4-dependent activation of NF-kappa-B. Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS. Heterogeneous homopolymer formed from homodimers; disulfide-linked. Belongs to the lipopolysaccharide (LPS) receptor complex, a multi-protein complex containing at least CD14, LY96 and TLR4. Ligand binding induces interaction with TLR4 and oligomerization of the complex. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 8q21.11. Cellular Component: extracellular space; plasma membrane; lipopolysaccharide receptor complex; endosome membrane. Molecular Function: protein binding; lipopolysaccharide receptor activity; coreceptor activity. Biological Process: I-kappaB kinase/NF-kappaB cascade; MyD88-independent toll-like receptor signaling pathway; positive regulation of lipopolysaccharide-mediated signaling pathway; response to lipopolysaccharide; toll-like receptor 3 signaling pathway; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; cell surface receptor linked signal transduction; detection of lipopolysaccharide; toll-like receptor signaling pathway; lipopolysaccharide-mediated signaling pathway; innate immune response; cellular defense response; inflammatory response; toll-like receptor 4 signaling pathway

size1 :

0.1 mg

price1 :

345 USD

more info or order :

MyBioSource product webpage