IL-33 Antibody [12H6D12] | MyBioSource MBS150019 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

IL-33 Antibody [12H6D12]

catalog :

MBS150019

quantity :

0.1 mg

price :

345 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

12H6D12

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS150019

products type :

Antibody

products full name :

IL-33 Antibody [12H6D12]

products short name :

IL-33

products name syn :

IL-33 Antibody [12H6D12] : DVS27; IL1F11; NF-HEV; NFEHEV; C9orf26; interleukin 33

other names :

interleukin-33 isoform 1; Interleukin-33; interleukin-33; IL-33; IL-1F11; DVS27-related protein; interleukin-1 family member 11; nuclear factor for high endothelial venules; nuclear factor from high endothelial venules; interleukin 33; Interleukin-1 family member 11; IL-1F11; Nuclear factor from high endothelial venules; NF-HEV

products gene name :

IL33

other gene names :

IL33; IL33; DVS27; IL1F11; NF-HEV; NFEHEV; C9orf26; C9orf26; IL1F11; NFHEV; IL-33; IL-1F11; NF-HEV

uniprot entry name :

IL33_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

12H6D12

host :

Mouse

reactivity :

Human, Mouse

sequence length :

270

purity :

IL-33 Monoclonal Antibody is immunoaffinity chromotography purified IgG.

form :

Liquid

concentration :

1 mg/mL

storage stability :

IL-33 monoclonal antibody can be stored at -20 degree C, stable for one year.

tested application :

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

app notes :

IL-33 antibody can be used for the detection of IL-33 by Western blot at 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 5 mug/mL.

other info1 :

Conjugate: Unconjugated. Immunogen: Mouse monoclonal IL-33 antibody was raised against the recombinant IL-33 protein. Buffer: IL-33 Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.

products description :

IL-33 Monoclonal Antibody: Interleukin-33 (IL-33) is a recently identified member of the IL-1 family of cytokines whose other members include IL-1 , IL-1Ra and IL-18. Its receptor has been shown to be ST2, an IL-1 receptor family member that also acts as a negative regulator of TLR-IL-1R signaling and IL-1R accessory protein (IL-1RAcP). Receptor binding of IL-33 activates NF- B and MAP kinases and induces the expression of TH2-associated cytokines such as IL-4, IL-5 and IL-6. Prolonged IL-33 treatment of mice led to the development of eosinophilia, splenomegaly, and severe pathological changes in mucosal organs such as lungs, esophagus and small intestine. Recent experiments have shown that IL-33 can also co-localize with heterochromatin and possesses transcriptional repressor activities, indicating that IL-33 may function as both a proinflammatory cytokine and an intracellular nuclear factor with transcriptional regulatory properties. Despite its predicted molecular weight, IL-33 will often run at higher molecular weight in SDS-PAGE.

ncbi gi num :

15559209

ncbi acc num :

NP_254274

ncbi gb acc num :

NM_033439.3

uniprot acc num :

O95760

ncbi mol weight :

16,250 Da

ncbi pathways :

Cytosolic DNA-sensing Pathway (125137); Cytosolic DNA-sensing Pathway (124833); Influenza A Pathway (217173); Influenza A Pathway (217150)

ncbi summary :

IL33 (MIM 608678) is a member of the IL1 (see MIM 147760) family that potently drives production of T helper-2 (Th2)-associated cytokines (e.g., IL4; MIM 147780). IL33 is a ligand for IL33R (IL1RL1; MIM 601203), an IL1 family receptor that is selectively expressed on Th2 cells and mast cells (summary by Yagami et al., 2010 [PubMed 20926795]).[supplied by OMIM, Jan 2011]

uniprot summary :

IL33: Cytokine that binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Induces T-helper type 2-associated cytokines. Belongs to the IL-1 family. Highly divergent. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Cytokine. Chromosomal Location of Human Ortholog: 9p24.1. Cellular Component: extracellular space; transport vesicle; chromosome; nucleus. Molecular Function: protein binding; cytokine activity. Biological Process: negative regulation of T-helper 1 type immune response; positive regulation of T-helper 2 type immune response; T-helper 2 type immune response; transcription, DNA-dependent; positive regulation of interleukin-6 production; positive regulation of immunoglobulin secretion; negative regulation of leukocyte migration; positive regulation of interleukin-4 production; negative regulation of immunoglobulin secretion; negative regulation of interferon-gamma production; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of transcription from RNA polymerase II promoter; positive regulation of interleukin-13 production; positive regulation of interleukin-5 production; positive regulation of inflammatory response; positive regulation of macrophage activation

size1 :

0.1 mg

price1 :

345 USD

more info or order :

MyBioSource product webpage