antibody

DC-SIGN Antibody [5D7]

MBS150015

0.1 mg

345 USD

monoclonal

mouse

nonconjugated

5D7

western blot, ELISA, immunohistochemistry, enzyme immunoassay

Antibody

DC-SIGN Antibody [5D7]

DC-SIGN

DC-SIGN Antibody [5D7] : CDSIGN; CLEC4L; DC-SIGN; DC-SIGN1; CD209 molecule

CD209 antigen; CD209 antigen; CD209 antigen; HIV gpl20-binding protein; C-type lectin domain family 4 member L; C-type lectin domain family 4, member L; dendritic cell-specific ICAM-3-grabbing non-integrin 1; dendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbing non-integrin; CD209 molecule; C-type lectin domain family 4 member L; Dendritic cell-specific ICAM-3-grabbing non-integrin 1; DC-SIGN; DC-SIGN1; CD_antigen: CD209

CD209

CD209; CD209; CDSIGN; CLEC4L; DC-SIGN; DC-SIGN1; CLEC4L; DC-SIGN; DC-SIGN1

CD209_HUMAN

Monoclonal

5D7

Mouse

Human

404

DC-SIGN Monoclonal Antibody is immunoaffinity chromotography purified IgG.

Liquid

1 mg/mL

DC-SIGN monoclonal antibody can be stored at -20 degree C, stable for one year.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

DC-SIGN antibody can be used for detection of DC-SIGN in Western Blot at 1 - 2 mg/mL and in immunohistochemistry at 5 - 10 mg/mL.

Conjugate: Unconjugated. Immunogen: A recombinant His-tagged protein fragment corresponding to the extracellular region of human DC-SIGN. Buffer: DC-SIGN Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.

DC-SIGN Monoclonal Antibody: Dendritic cells (DCs) that control immune responses were recently found to capture and transport HIV from the mucosal area to remote lymph nodes, where DCs hand over HIV to CD4+ T lymphocytes. DCs also amplify the amount of virus and extend the duration of viral infectivity. Multiple strains of HIV-1, HIV-2 and SIV bind to DCs via DC-SIGN. ICAM-3 is the natural ligand for DC-SIGN. A DC-SIGN homologue (termed DC-SIGNR, L-SIGN, and DC-SIGN2) was identified recently. DC-SIGN forms a novel gene family with DC-SIGNR and many alternatively spliced isoforms of DC-SIGN and DC-SIGNR. The expression of DC-SIGN was found in mucosal tissues including placenta, small intestine, and rectum.

46396012

Q9NNX6.1

Q9NNX6

33,874 Da

Measles Pathway 213306!!Measles Pathway 213277!!Phagosome Pathway 153910!!Phagosome Pathway 153859!!Tuberculosis Pathway 213780!!Tuberculosis Pathway 213743

This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332; often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.[provided by RefSeq, Feb 2009]

0.1 mg

345 USD