antibody

PD-1 Antibody [12A7D7]

MBS150009

0.1 mg

345 USD

monoclonal

mouse

nonconjugated

12A7D7

human, mouse, rat

western blot, ELISA, immunohistochemistry, enzyme immunoassay, immunohistochemistry - paraffin section

Antibody

PD-1 Antibody [12A7D7]

PD-1

PD-1 Antibody [12A7D7] : PD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; hSLE1; programmed cell death 1

programmed cell death 1; Programmed cell death protein 1; programmed cell death protein 1; mPD-1; protein PD-1; programmed cell death 1; CD_antigen: CD279

PDCD1

Pdcd1; PDCD1; PD-1; Pdc1; Ly101; PD1; Protein PD-1; hPD-1

PDCD1_HUMAN

Monoclonal

IgG1

12A7D7

Mouse

Human, Mouse, Rat

288

PD-1 Monoclonal Antibody is immunoaffinity chromotography purified IgG.

Liquid

1 mg/mL

PD-1 monoclonal antibody can be stored at -20 degree C, stable for one year.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC-P)

PD-1 antibody can be used for detection of PD-1 by Western blot at 1 ug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. Optimal dilutions for each application to be determined by the researcher. Positive Control: MBS153298-PD-1 Recombinant Protein.

Conjugate: Unconjugated. Immunogen: A ~150 amino acid recombinant protein from near the amino terminus of mouse PD-1. Accession No.: EDL39922

Buffer: PD-1 Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.

PD-1 Monoclonal Antibody: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "danger signals" such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at higher molecular weight in SDS-PAGE.

148707975

EDL39922

Q15116

31,647 Da

Adaptive Immune System Pathway (1110669); Cell Adhesion Molecules (CAMs) Pathway (83266); Cell Adhesion Molecules (CAMs) Pathway (480); Costimulation By The CD28 Family Pathway (1110675); Immune System Pathway (1110668); PD-1 Signaling Pathway (1110680); T Cell Receptor Signaling Pathway (83277); T Cell Receptor Signaling Pathway (491)

PDCD1: a single-pass type I membrane protein. A negative regulator of activated T cells, is upregulated in human and mouse exhausted T cells during persistent viral infection. A marker of angioimmunoblastic T-cell lymphoma and germinal center associated T cells. Protein type: Membrane protein, integral; Apoptosis. Chromosomal Location of Human Ortholog: 2q37.3. Cellular Component: integral to membrane; plasma membrane; external side of plasma membrane. Molecular Function: signal transducer activity; protein binding. Biological Process: apoptosis; multicellular organismal development; T cell costimulation; signal transduction; humoral immune response. Disease: Systemic Lupus Erythematosus

0.1 mg

345 USD