CLEC4E Antibody, Biotin conjugated | MyBioSource MBS1497212 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

CLEC4E Antibody, Biotin conjugated

catalog :

MBS1497212

quantity :

0.05 mg

price :

160 USD

clonality :

polyclonal

host :

rabbit

conjugate :

biotin

reactivity :

human, mouse

application :

ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS1497212

products type :

Antibody

products full name :

CLEC4E Antibody, Biotin conjugated

products short name :

[CLEC4E]

products name syn :

[C-type lectin domain family 4 member E; CLEC4E; CLECSF9; MINCLE; UNQ218/PRO244; C-type lectin superfamily member 9; Macrophage-inducible C-type lectin]

other names :

[C-type lectin domain family 4 member E; C-type lectin domain family 4 member E; C-type lectin domain family 4 member E; C-type lectin domain family 4 member E; C-type lectin superfamily member 9; Macrophage-inducible C-type lectin]

products gene name :

[CLEC4E]

other gene names :

[CLEC4E; CLEC4E; MINCLE; CLECSF9; CLECSF9; MINCLE]

uniprot entry name :

CLC4E_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse

sequence length :

219

purity :

>95%, Protein G Purified

storage stability :

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

tested application :

ELISA (EIA)

other info1 :

Storage Buffer: Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. Conjugate: Biotin

other info2 :

Immunogen: Recombinant human C-type lectin domain family 4 member E protein. Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-161488

products description :

C-type lectin that functions as cell-surface receptor for a wide variety of ligands such as damaged cells, fungi and mycobacteria. Plays a role in the recognition of pathogenic fungi, such as Candida albicans. The detection of mycobacteria is via trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid. Specifically recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia. Recognizes also SAP130, a nuclear protein, that is released by dead or dying cells. Transduces signals through an ITAM-containing adapter protein, Fc receptor gamma chain /FCER1G. Induces secretion of inflammatory cytokines through a pathway that depends on SYK, CARD9 and NF-kappa-B.

ncbi gi num :

7657333

ncbi acc num :

NP_055173.1

ncbi gb acc num :

NM_014358.3

uniprot acc num :

Q9ULY5

ncbi mol weight :

25,073 Da

ncbi pathways :

C-type Lectin Receptors (CLRs) Pathway (1269303); Dectin-2 Family Pathway (1269308); Immune System Pathway (1269170); Innate Immune System Pathway (1269203); Tuberculosis Pathway (213780); Tuberculosis Pathway (213743)

ncbi summary :

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein is a downstream target of CCAAT/enhancer binding protein (C/EBP), beta (CEBPB) and may play a role in inflammation. Alternative splice variants have been described but their full-length sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]

uniprot summary :

CLEC4E: C-type lectin that functions as cell-surface receptor for a wide variety of ligands such as damaged cells, fungi and mycobacteria. Plays a role in the recognition of pathogenic fungi, such as Candida albicans. The detection of mycobacteria is via trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid. Specifically recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia. Recognizes also SAP130, a nuclear protein, that is released by dead or dying cells. Transduces signals through an ITAM-containing adapter protein, Fc receptor gamma chain /FCER1G. Induces secretion of inflammatory cytokines through a pathway that depends on SYK, CARD9 and NF-kappa-B. Protein type: Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 12p13.31. Cellular Component: integral to membrane; plasma membrane. Molecular Function: carbohydrate binding; receptor activity. Biological Process: defense response to bacterium; innate immune response; positive regulation of cytokine secretion; stimulatory C-type lectin receptor signaling pathway; T cell differentiation during immune response

size1 :

0.05 mg

price1 :

160 USD

size2 :

0.1 mg

price2 :

235

more info or order :

MyBioSource product webpage