Rabbit anti-human Serglycin polyclonal Antibody(SRGN) | MyBioSource MBS1495765 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit anti-human Serglycin polyclonal Antibody(SRGN)

catalog :

MBS1495765

quantity :

0.05 mL

price :

120 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

All lanes: Serglycin antibody at 9ug/ml. Lane 1:THP-1 whole cell lysate. Lane 2:HL-60 whole cell lysate. Secondary. Goat polyclonal to rabbit at 1/10000 dilution. Predicted band size: 18kDa. Observed band size: 18kDa.

image 2 :

Immunohistochemistry of paraffin-embedded human spleen using MBS1495765 at dilution 1:100

product information

catalog number :

MBS1495765

products type :

Antibody

products full name :

Rabbit anti-human Serglycin polyclonal Antibody(SRGN)

products short name :

[Serglycin]

products name syn :

[Serglycin (Hematopoietic proteoglycan core protein) (Platelet proteoglycan core protein) (P.PG) (Secretory granule proteoglycan core protein), SRGN, PRG, PRG1]

other names :

[serglycin; Serglycin; serglycin; serglycin; Hematopoietic proteoglycan core protein; Platelet proteoglycan core protein; P.PG; Secretory granule proteoglycan core protein]

products gene name :

[SRGN]

other gene names :

[SRGN; SRGN; PPG; PRG; PRG1; PRG; PRG1; P.PG]

uniprot entry name :

SRGN_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human

sequence length :

158

purity :

Antigen Affinity Purified

form :

Liquid; PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

storage stability :

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

tested application :

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

app notes :

WB: 1:500-1:2000. IHC: 1:20-1:200

image1 heading :

Western Blot (WB)

image2 heading :

Immunohistochemistry (IHC)

other info1 :

Conjugate: Non-conjugated. Research Area: Cell Biology. Target Names: SRGN

other info2 :

Immunogen: Recombinant human Serglycin protein(28-158aa). Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-28007 / sc-28008 / sc-292311

products description :

Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of someproteases in both connective tissue and mucosal mast cells and for storage ofgranzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase inazurophil granules of neutrophils. Mediates processing of MMP2. Plays a role incytotoxic cell granule-mediated apoptosis by forming a complex with granzymeB which is delivered to cells by perforin to induce apoptosis. Regulates thesecretion of TNF-alpha and may also regulate protease secretion. Inhibits bonemineralization.

ncbi gi num :

45935371

ncbi acc num :

NP_002718.2

ncbi gb acc num :

NM_002727.2

uniprot acc num :

P10124

ncbi pathways :

Hemostasis Pathway (1269340); Platelet Activation, Signaling And Aggregation Pathway (1269350); Platelet Degranulation Pathway (1269367); Response To Elevated Platelet Cytosolic Ca2+ Pathway (1269365)

ncbi summary :

This gene encodes a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be important for neutralizing hydrolytic enzymes. This encoded protein was found to be associated with the macromolecular complex of granzymes and perforin, which may serve as a mediator of granule-mediated apoptosis. Two transcript variants, only one of them protein-coding, have been found for this gene. [provided by RefSeq, Jul 2010]

uniprot summary :

SRGN: Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF- alpha and may also regulate protease secretion. Inhibits bone mineralization. Belongs to the serglycin family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 10q22.1. Cellular Component: extracellular region; extracellular space; Golgi apparatus; Golgi membrane; mast cell granule. Molecular Function: collagen binding; protein binding. Biological Process: biomineral formation; blood coagulation; induction of apoptosis by granzyme; maintenance of granzyme B localization in T cell secretory granule; maintenance of protease localization in mast cell secretory granule; mast cell secretory granule organization and biogenesis; negative regulation of bone mineralization; negative regulation of cytokine secretion; platelet activation; platelet degranulation; protease localization in mast cell secretory granule; protein processing; T cell secretory granule organization and biogenesis

size1 :

0.05 mL

price1 :

120 USD

size2 :

0.1 mL

price2 :

160

more info or order :

MyBioSource product webpage