Rabbit anti-human Claudin-14 polyclonal Antibody(CLDN14) | MyBioSource MBS1494658 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit anti-human Claudin-14 polyclonal Antibody(CLDN14)

catalog :

MBS1494658

quantity :

0.05 mL

price :

120 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

All lanes: Claudin-14 antibody at 4ug/ml. Lane 1:rat liver tissue. Lane 2:mouse kidney tissue. Lane 3:Hela whole cell lysate. Secondary. Goat polyclonal to rabbit at 1/10000 dilution. Predicted band size: 26kDa. Observed band size: 26kDa.

image 2 :

Immunohistochemistry of paraffin-embedded human kidney using MBS1494658 at dilution 1:100

image 3 :

Immunohistochemistry of paraffin-embedded human pancreas tissue using MBS1494658 at dilution 1:100

product information

catalog number :

MBS1494658

products type :

Antibody

products full name :

Rabbit anti-human Claudin-14 polyclonal Antibody(CLDN14)

products short name :

[Claudin-14]

products name syn :

[Claudin-14, CLDN14]

other names :

[claudin-14; Claudin-14; claudin-14; claudin 14]

products gene name :

[CLDN14]

other gene names :

[CLDN14; CLDN14; DFNB29]

uniprot entry name :

CLD14_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

239

purity :

Antigen Affinity Purified

form :

Liquid; PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

storage stability :

Upon receipt store at -20°C at -80°C. Avoid freeze.

tested application :

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

app notes :

WB: 1:200-1000. IHC: 1:20-1:200

image1 heading :

Western Blot (WB)

image2 heading :

Immunohistochemistry (IHC)

image3 heading :

Immunohistochemistry (IHC)

other info1 :

Conjugate: Non-conjugated

other info2 :

Immunogen: Recombinant human Claudin-14 protein (140-239aa). Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-47842 / sc-135211

products description :

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

ncbi gi num :

225703138

ncbi acc num :

NP_001139549.1

ncbi gb acc num :

NM_001146077.1

uniprot acc num :

O95500

ncbi pathways :

Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480); Cell Junction Organization Pathway (1270232); Cell-Cell Communication Pathway (1270231); Cell-cell Junction Organization Pathway (1270233); Hepatitis C Pathway (173973); Hepatitis C Pathway (173907); Leukocyte Transendothelial Migration Pathway (83083); Leukocyte Transendothelial Migration Pathway (494); Tight Junction Pathway (83071)

ncbi summary :

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. The encoded protein also binds specifically to the WW domain of Yes-associated protein. Defects in this gene are the cause of an autosomal recessive form of nonsyndromic sensorineural deafness. It is also reported that four synonymous variants in this gene are associated with kidney stones and reduced bone mineral density. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2010]

uniprot summary :

Claudin-14: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. Defects in CLDN14 are the cause of deafness autosomal recessive type 29 (DFNB29). DFNB29 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Belongs to the claudin family. Protein type: Membrane protein, multi-pass; Cell adhesion; Membrane protein, integral. Chromosomal Location of Human Ortholog: 21q22.3. Cellular Component: endoplasmic reticulum; integral to membrane; plasma membrane; tight junction. Molecular Function: identical protein binding; structural molecule activity. Biological Process: calcium-independent cell-cell adhesion; intercellular junction assembly and maintenance; protein complex assembly. Disease: Deafness, Autosomal Recessive 29

size1 :

0.05 mL

price1 :

120 USD

size2 :

0.1 mL

price2 :

160

more info or order :

MyBioSource product webpage