antibody

COLEC11 Antibody

MBS1493787

0.05 mL

120 USD

polyclonal

rabbit

nonconjugated

human, rat

western blot, ELISA, immunohistochemistry, enzyme immunoassay

Antibody

COLEC11 Antibody

[COLEC11]

[Collectin kidney protein 1; CL-K1; COLEC11]

[collectin-11 isoform c; Collectin-11; collectin-11; collectin subfamily member 11; Collectin kidney protein 1; CL-K1]

[COLEC11]

[COLEC11; COLEC11; 3MC2; CLK1; CL-K1-I; CL-K1-II; CL-K1-IIa; CL-K1-IIb; CL-K1]

COL11_HUMAN

Polyclonal

IgG

Rabbit

Human, Rat

247

Antigen Affinity Purified

Liquid; PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

Recommended dilution: WB:1:500-2000. IHC:1:20-1:200

Western Blot (WB)

Immunohistochemistry (IHC)

Conjugate: Non-conjugated

Immunogen: Recombinant human Collectin-11 protein (26-271aa). Species: Human. Research Area: Cell Biology. Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-242495 / sc-242497

Lectin that binds to various sugars including fucose and mannose. Has a higher affinity for fucose compared to mannose. Does not bind to glucose, N-acetylglucosamine and N-acetylgalactosamine. Also binds lipopolysaccharides (LPS). Involved in fundamental development serving as a guidance cue for neural crest cell migration (By similarity).

364502941

NP_001242911.1

NM_001255982.1

Q9BWP8

Binding And Uptake Of Ligands By Scavenger Receptors Pathway (1269897); Phagosome Pathway (153910); Phagosome Pathway (153859); Scavenging By Class A Receptors Pathway (1269899); Vesicle-mediated Transport Pathway (1269876)

This gene encodes a member of the collectin family of C-type lectins that possess collagen-like sequences and carbohydrate recognition domains. Collectins are secreted proteins that play important roles in the innate immune system by binding to carbohydrate antigens on microorganisms, facilitating their recognition and removal. The encoded protein binds to multiple sugars with a preference for fucose and mannose. Mutations in this gene are a cause of 3MC syndrome-2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

COLEC11: Lectin that binds to various sugars including fucose and mannose. Has a higher affinity for fucose compared to mannose. Does not bind to glucose, N-acetylglucosamine and N- acetylgalactosamine. Also binds lipopolysaccharides (LPS). Involved in fundamental development serving as a guidance cue for neural crest cell migration. Defects in COLEC11 are the cause of 3MC syndrome type 2 (3MC2). 3MC2 is an a disorder characterized by facial dysmorphism that includes hypertelorism, blepharophimosis, blepharoptosis and highly archedDE eyebrows, cleft lip and/or palate, craniosynostosis, learning disability and genital, limb and vesicorenal anomalies. The term 3MC syndrome includes Carnevale, Mingarelli, Malpuech, and Michels syndromes. Belongs to the COLEC10/COLEC11 family. 9 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 2p25.3. Cellular Component: collagen; extracellular region. Molecular Function: mannose binding. Biological Process: developmental process; multicellular organismal development; receptor-mediated endocytosis. Disease: 3mc Syndrome 2

0.05 mL

120 USD

0.1 mL

160