catalog number :
MBS1491961
products full name :
Rabbit anti-human Aquaporin-4 polyclonal Antibody(AQP4)
products short name :
[Aquaporin-4]
products name syn :
[Aquaporin-4 (AQP-4) (Mercurial-insensitive water channel) (MIWC) (WCH4),AQP4]
other names :
[aquaporin-4 isoform M1; Aquaporin-4; aquaporin-4; aquaporin 4; Mercurial-insensitive water channel; MIWC; WCH4]
products gene name :
[AQP4]
other gene names :
[AQP4; AQP4; MIWC; WCH4; AQP-4; MIWC]
uniprot entry name :
AQP4_HUMAN
reactivity :
Human, Mouse
purity :
Antigen Affinity Purified
form :
Liquid. PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
storage stability :
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
tested application :
ELISA (EIA), Western Blot (WB)
app notes :
Recommended dilution: WB:1:500-2000
image1 heading :
Western Blot (WB)
other info1 :
Conjugate: Non-conjugated. Species: Human. Research Area: Signal Transduction. Target Names: AQP4
other info2 :
Immunogen: Recombinant human Aquaporin-4 protein (244-323aa). Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-9887 / sc-9888 / sc-20812
products description :
Forms a water-specific channel. Osmoreceptor which regulates body water balance and mediates water flow within the central nervous system.
ncbi acc num :
NP_001641.1
ncbi gb acc num :
NM_001650.5
ncbi pathways :
Aquaporin-mediated Transport Pathway (1269944); Bile Secretion Pathway (193146); Bile Secretion Pathway (193095); Passive Transport By Aquaporins Pathway (1269945); SIDS Susceptibility Pathways (198901); Spinal Cord Injury Pathway (739007); Transmembrane Transport Of Small Molecules Pathway (1269903); Vasopressin Regulates Renal Water Homeostasis Via Aquaporins Pathway (1269946); Vasopressin-regulated Water Reabsorption Pathway (143700); Vasopressin-regulated Water Reabsorption Pathway (143631)
ncbi summary :
This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. This protein is the predominant aquaporin found in brain and has an important role in brain water homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2015]
uniprot summary :
AQP4: a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. The predominant aquaporin found in brain. Two alternatively spliced transcript variants have been described. Protein type: Channel, misc.; Transporter; Membrane protein, multi-pass; Transporter, aquaporin family; Membrane protein, integral. Chromosomal Location of Human Ortholog: 18q11.2-q12.1. Cellular Component: basolateral plasma membrane; cytoplasm; external side of plasma membrane; integral to membrane; plasma membrane. Molecular Function: glycerol channel activity; water channel activity; water transporter activity. Biological Process: glycerol transport; multicellular organismal water homeostasis; renal water homeostasis; transmembrane transport; transport; water transport