catalog number :
MBS1491066
products full name :
Rabbit anti-human Nicotinate phosphoribosyltransferase polyclonal Antibody
products short name :
Nicotinate phosphoribosyltransferase
products name syn :
FHA-HIT-interacting protein Nicotinate phosphoribosyltransferase domain-containing protein 1 NAPRT1 FHIP
other names :
nicotinate phosphoribosyltransferase isoform 2; Nicotinate phosphoribosyltransferase; nicotinate phosphoribosyltransferase; nicotinate phosphoribosyltransferase; FHA-HIT-interacting protein; Nicotinate phosphoribosyltransferase domain-containing protein 1
other gene names :
NAPRT; NAPRT; NAPRT1; PP3856; FHIP; NAPRT1; NAPRTase
uniprot entry name :
PNCB_HUMAN
reactivity :
Human, Mouse. Other species are not tested. Please decide the specificity by homology
purity :
Caprylic Acid Ammonium Sulfate Precipitation Purified
storage stability :
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
tested application :
ELISA (EIA), Wetsern Blot (WB)
other info1 :
Storage Buffer: Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. Conjugate: Non-conjugated
other info2 :
Immunogen: Recombinant human Nicotinate phosphoribosyltransferase protein
products description :
Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN). Essential for NA to increase cellular NAD levels and prevent oxidative stress of the cells.
ncbi acc num :
NP_001273758.1
ncbi gb acc num :
NM_001286829.1
ncbi mol weight :
56,099 Da
ncbi pathways :
Metabolic Pathways (132956); Metabolism Pathway (1269956); Metabolism Of Vitamins And Cofactors Pathway (1270144); Metabolism Of Water-soluble Vitamins And Cofactors Pathway (1270145); Nicotinamide Salvaging Pathway (1270155); Nicotinate And Nicotinamide Metabolism Pathway (83014); Nicotinate And Nicotinamide Metabolism Pathway (400); Nicotinate Metabolism Pathway (1270154)
ncbi summary :
Nicotinic acid (NA; niacin) is converted by nicotinic acid phosphoribosyltransferase (NAPRT; EC 2.4.2.11) to NA mononucleotide (NaMN), which is then converted to NA adenine dinucleotide (NaAD), and finally to nicotinamide adenine dinucleotide (NAD), which serves as a coenzyme in cellular redox reactions and is an essential component of a variety of processes in cellular metabolism including response to stress (Hara et al., 2007).[supplied by OMIM, Mar 2008]
uniprot summary :
NAPRT1: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN). Essential for NA to increase cellular NAD levels and prevent oxidative stress of the cells. Belongs to the NAPRTase family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: EC 6.3.4.21; Transferase. Chromosomal Location of Human Ortholog: 8q24.3. Cellular Component: cytoplasm; cytosol; Golgi apparatus; nucleus. Molecular Function: ligase activity; nicotinate phosphoribosyltransferase activity; nicotinate-nucleotide diphosphorylase (carboxylating) activity; protein binding. Biological Process: NAD biosynthetic process; NAD metabolic process; nicotinamide metabolic process; nicotinate nucleotide salvage; response to oxidative stress; vitamin metabolic process; water-soluble vitamin metabolic process