Rabbit anti-human Decorin polyclonal Antibody, HRP conjugated | MyBioSource MBS1490703 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit anti-human Decorin polyclonal Antibody, HRP conjugated

catalog :

MBS1490703

quantity :

0.05 mg

price :

160 USD

clonality :

polyclonal

host :

rabbit

conjugate :

HRP

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS1490703

products type :

Antibody

products full name :

Rabbit anti-human Decorin polyclonal Antibody, HRP conjugated

products short name :

Decorin

products name syn :

Bone proteoglycan II; PG-S2; PG40; SLRR1B

other names :

decorin isoform a preproprotein; Decorin; decorin; decorin; Bone proteoglycan II; PG-S2; PG40

products gene name :

DCN

other gene names :

DCN; DCN; CSCD; PG40; PGII; PGS2; DSPG2; SLRR1B; SLRR1B

uniprot entry name :

PGS2_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human

sequence length :

359

purity :

Caprylic Acid Ammonium Sulfate Precipitation Purified

storage stability :

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

tested application :

ELISA (EIA), Wetsern Blot (WB), Immunohistochemistry (IHC)

other info1 :

Storage Buffer: Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. Conjugate: HRP

other info2 :

Immunogen: Recombinant human Decorin protein

products description :

May affect the rate of fibrils formation.

ncbi gi num :

4503271

ncbi acc num :

NP_001911.1

ncbi gb acc num :

NM_001920.4

uniprot acc num :

P07585

ncbi mol weight :

8,266 Da

ncbi pathways :

A Tetrasaccharide Linker Sequence Is Required For GAG Synthesis Pathway (1269981); CS/DS Degradation Pathway (1269987); Chondroitin Sulfate Biosynthesis Pathway (1269985); Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway (1269984); Defective B3GALT6 Causes EDSP2 And SEMDJL1 Pathway (1309217); Defective B3GAT3 Causes JDSSDHD Pathway (1269015); Defective B4GALT7 Causes EDS, Progeroid Type Pathway (1269014); Defective CHST14 Causes EDS, Musculocontractural Type Pathway (1269018); Defective CHST3 Causes SEDCJD Pathway (1269017); Defective CHSY1 Causes TPBS Pathway (1269016)

ncbi summary :

This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients. [provided by RefSeq, Nov 2015]

uniprot summary :

DCN: May affect the rate of fibrils formation. Defects in DCN are the cause of congenital stromal corneal dystrophy (CSCD). Corneal dystrophies are inherited, bilateral, primary alterations of the cornea that are not associated with prior inflammation or secondary to systemic disease. Most show autosomal dominant inheritance. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. 5 isoforms of the human protein are produced by alternative splicing. Protein type: Motility/polarity/chemotaxis; Extracellular matrix; Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 12q21.33. Cellular Component: collagen type VI; cytoplasm; extracellular matrix; extracellular region; extracellular space; Golgi lumen; lysosomal lumen. Molecular Function: collagen binding; extracellular matrix binding; glycosaminoglycan binding; protein kinase inhibitor activity; protein N-terminus binding. Biological Process: aging; carbohydrate metabolic process; chondroitin sulfate biosynthetic process; chondroitin sulfate catabolic process; chondroitin sulfate metabolic process; cytokine and chemokine mediated signaling pathway; dermatan sulfate biosynthetic process; extracellular matrix disassembly; extracellular matrix organization and biogenesis; glycosaminoglycan metabolic process; kidney development; negative regulation of angiogenesis; negative regulation of JAK-STAT cascade; negative regulation of protein kinase activity; organ morphogenesis; peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan; placenta development; positive regulation of autophagy; positive regulation of macroautophagy; positive regulation of mitochondrial depolarization; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of transcription from RNA polymerase II promoter; response to lipopolysaccharide; response to mechanical stimulus; skeletal muscle development; wound healing. Disease: Corneal Dystrophy, Congenital Stromal

size1 :

0.05 mg

price1 :

160 USD

size2 :

0.1 mg

price2 :

235

more info or order :

MyBioSource product webpage