catalog number :
MBS1490460
products full name :
Rabbit anti-Bordetella pertussis Pertussis toxin subunit 1 polyclonal Antibody
products short name :
[Bordetella pertussis Pertussis toxin subunit 1]
products name syn :
[Islet-activating protein S1 NAD-dependent ADP-ribosyltransferase ptxA BP3783]
other names :
[pertussis toxin subunit 1; Pertussis toxin subunit 1; pertussis toxin subunit 1; Islet-activating protein S1; IAP S1; NAD-dependent ADP-ribosyltransferase (EC:2.4.2.-)]
other gene names :
[ptxA; ptxA; PTX S1; IAP S1]
uniprot entry name :
TOX1_BORPE
reactivity :
Bordetella pertussis
purity :
>95%, Protein G Purified
storage stability :
Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.
tested application :
ELISA (EIA), Western Blot (WB)
app notes :
WB: 1:1000-1:5000
image1 heading :
Western Blot (WB)
other info1 :
Storage Buffer: Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. Conjugate: Non-conjugated
other info2 :
Immunogen: Recombinant Bordetella pertussis Pertussis toxin subunit 1 protein (35-269AA). Species: Bordetella pertussis. Research Area: Others
products description :
S1 is an NAD-dependent ADP-ribosyltransferase, which plays a crucial role in the pathogenesis of B.pertussis causing disruption of normal host cellular regulation. It catalyzes the ADP-ribosylation of a cysteine in the alpha subunit of host heterotrimeric G proteins. In the absence of G proteins it also catalyzes the cleavage of NAD+ into ADP-ribose and nicotinamide. It irreversibly uncouples the G-alpha GTP-binding proteins from their membrane receptors.
ncbi acc num :
NP_882282.1
ncbi gb acc num :
NC_002929.2
ncbi pathways :
Pertussis Pathway (218102); Pertussis Pathway (218099); Pertussis Pathogenicity Signature 1, Pertussis Toxin Pathway (704416); Pertussis Pathogenicity Signature 1, Pertussis Toxin Pathway (705375)
uniprot summary :
S1 is an NAD-dependent ADP-ribosyltransferase, which plays a crucial role in the pathogenesis of B.pertussis causing disruption of normal host cellular regulation. It catalyzes the ADP-ribosylation of a cysteine in the alpha subunit of host heterotrimeric G proteins. In the absence of G proteins it also catalyzes the cleavage of NAD+ into ADP-ribose and nicotinamide. It irreversibly uncouples the G-alpha GTP-binding proteins from their membrane receptors.