Rabbit anti-mouse Hemoglobin subunit alpha polyclonal Antibody | MyBioSource MBS1489797 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit anti-mouse Hemoglobin subunit alpha polyclonal Antibody

catalog :

MBS1489797

quantity :

0.05 mg

price :

160 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS1489797

products type :

Antibody

products full name :

Rabbit anti-mouse Hemoglobin subunit alpha polyclonal Antibody

products short name :

Hemoglobin subunit alpha

products name syn :

Alpha-globin Hemoglobin alpha chain Hba Hba-a1

other names :

Hemoglobin subunit alpha; Hemoglobin subunit alpha; hemoglobin subunit alpha; hemoglobin alpha, adult chain 1; Alpha-globin; Hemoglobin alpha chain

other gene names :

Hba-a1; Hba; Hba; Hba1; Hbat1; Hba-a1

uniprot entry name :

HBA_MOUSE

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Mouse, Human. Other species are not tested. Please decide the specificity by homology.

sequence length :

142

purity :

Caprylic Acid Ammonium Sulfate Precipitation Purified

storage stability :

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

tested application :

ELISA (EIA), Wetsern Blot (WB)

other info1 :

Storage Buffer: Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. Conjugate: Non-conjugated

other info2 :

Immunogen: Recombinant mouse Hemoglobin subunit alpha protein

ncbi gi num :

122441

ncbi acc num :

P01942.2

uniprot acc num :

P01942

ncbi mol weight :

15,085 Da

ncbi pathways :

African Trypanosomiasis Pathway (194387); African Trypanosomiasis Pathway (194323); Binding And Uptake Of Ligands By Scavenger Receptors Pathway (1324545); Erythrocytes Take Up Carbon Dioxide And Release Oxygen Pathway (1324490); Erythrocytes Take Up Oxygen And Release Carbon Dioxide Pathway (1324491); Malaria Pathway (152666); Malaria Pathway (152657); Metabolism Pathway (1324226); O2/CO2 Exchange In Erythrocytes Pathway (1324489); Scavenging Of Heme From Plasma Pathway (1324546)

uniprot summary :

HBA1: Involved in oxygen transport from the lung to the various peripheral tissues. Defects in HBA1 may be a cause of Heinz body anemias (HEIBAN). This is a form of non-spherocytic hemolytic anemia of Dacie type 1. After splenectomy, which has little benefit, basophilic inclusions called Heinz bodies are demonstrable in the erythrocytes. Before splenectomy, diffuse or punctate basophilia may be evident. Most of these cases are probably instances of hemoglobinopathy. The hemoglobin demonstrates heat lability. Heinz bodies are observed also with the Ivemark syndrome (asplenia with cardiovascular anomalies) and with glutathione peroxidase deficiency. Defects in HBA1 are the cause of alpha-thalassemia (A- THAL). The thalassemias are the most common monogenic diseases and occur mostly in Mediterranean and Southeast Asian populations. The hallmark of alpha-thalassemia is an imbalance in globin-chain production in the adult HbA molecule. The level of alpha chain production can range from none to very nearly normal levels. Deletion of both copies of each of the two alpha-globin genes causes alpha(0)-thalassemia, also known as homozygous alpha thalassemia. Due to the complete absence of alpha chains, the predominant fetal hemoglobin is a tetramer of gamma-chains (Bart hemoglobin) that has essentially no oxygen carrying capacity. This causes oxygen starvation in the fetal tissues leading to prenatal lethality or early neonatal death. The loss of three alpha genes results in high levels of a tetramer of four beta chains (hemoglobin H), causing a severe and life-threatening anemia known as hemoglobin H disease. Untreated, most patients die in childhood or early adolescence. The loss of two alpha genes results in mild alpha-thalassemia, also known as heterozygous alpha-thalassemia. Affected individuals have small red cells and a mild anemia (microcytosis). If three of the four alpha-globin genes are functional, individuals are completely asymptomatic. Some rare forms of alpha-thalassemia are due to point mutations (non- deletional alpha-thalassemia). The thalassemic phenotype is due to unstable globin alpha chains that are rapidly catabolized prior to formation of the alpha-beta heterotetramers. Alpha(0)-thalassemia is associated with non-immune hydrops fetalis, a generalized edema of the fetus with fluid accumulation in the body cavities due to non-immune causes. Non- immune hydrops fetalis is not a diagnosis in itself but a symptom, a feature of many genetic disorders, and the end-stage of a wide variety of disorders. Defects in HBA1 are the cause of hemoglobin H disease (HBH). HBH is a form of alpha-thalassemia due to the loss of three alpha genes. This results in high levels of a tetramer of four beta chains (hemoglobin H), causing a severe and life-threatening anemia. Untreated, most patients die in childhood or early adolescence. Belongs to the globin family. Protein type: Carrier. Cellular Component: hemoglobin complex; membrane. Molecular Function: haptoglobin binding; heme binding; organic acid binding; oxygen binding; peroxidase activity. Biological Process: erythrocyte development; in utero embryonic development

size1 :

0.05 mg

price1 :

160 USD

size2 :

0.1 mg

price2 :

235

more info or order :

MyBioSource product webpage