catalog number :
MBS1489729
products full name :
Rabbit anti-mouse Hyaluronan synthase 2 polyclonal Antibody, FITC
products short name :
Hyaluronan synthase 2
products name syn :
Hyaluronate synthase 2; Hyaluronic acid synthase 2; HA synthase 2
other names :
hyaluronan synthase 2; Hyaluronan synthase 2; hyaluronan synthase 2; hyaluronan synthase 2; Hyaluronate synthase 2; Hyaluronic acid synthase 2; HA synthase 2
products gene name :
Has2
other gene names :
Has2; Has2; HA synthase 2
uniprot entry name :
HYAS2_MOUSE
purity :
Caprylic Acid Ammonium Sulfate Precipitation Purified
storage stability :
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
tested application :
Western Blot (WB), ELISA (EIA). Not yet tested in other applications.
other info1 :
Storage Buffer: Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. Conjugate: FITC
other info2 :
Immunogen: Recombinant mouse Hyaluronan synthase 2 protein
products description :
Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction and it is particularly responsible for the synthesis of high molecular mass hyaluronan. Required for the transition of endocardial cushion cells into mesenchymal cells, a process crucial for heart development. May also play a role in vasculogenesis. High molecular mass hyaluronan also play a role in early contact inhibition a process which stops cell growth when cells come into contact with each other or the extracellular matrix.
ncbi acc num :
NP_032242.3
ncbi gb acc num :
NM_008216.3
ncbi mol weight :
63,510 Da
uniprot summary :
HAS2: Plays a role in hyaluronan/hyaluronic acid (HA) synthesis. Expressed in fibroblasts. Belongs to the nodC/HAS family. Protein type: EC 2.4.1.212; Membrane protein, multi-pass; Membrane protein, integral; Transferase; Motility/polarity/chemotaxis. Cellular Component: cytoplasm; integral to membrane; integral to plasma membrane; membrane. Molecular Function: hyaluronan synthase activity; transferase activity; transferase activity, transferring glycosyl groups. Biological Process: cell adhesion; extracellular polysaccharide biosynthetic process; hyaluronan biosynthetic process; hyaluronan metabolic process; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of keratinocyte migration; positive regulation of smooth muscle cell migration; vasculogenesis