Rabbit anti-human Transthyretin polyclonal Antibody | MyBioSource MBS1488827 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit anti-human Transthyretin polyclonal Antibody

catalog :

MBS1488827

quantity :

0.05 mg

price :

160 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS1488827

products type :

Antibody

products full name :

Rabbit anti-human Transthyretin polyclonal Antibody

products short name :

Transthyretin

products name syn :

ATTR; Prealbumin; TBPA; PALB

other names :

transthyretin; Transthyretin; transthyretin; transthyretin; ATTR; Prealbumin; TBPA

products gene name :

TTR

other gene names :

TTR; TTR; CTS; CTS1; PALB; TBPA; HEL111; HsT2651; PALB

uniprot entry name :

TTHY_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human

sequence length :

147

purity :

Caprylic Acid Ammonium Sulfate Precipitation Purified

storage stability :

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

tested application :

ELISA (EIA), Immunohistochemistry (IHC). Not yet tested in other applications.

other info1 :

Storage Buffer: Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. Conjugate: Non-conjugated

other info2 :

Immunogen: Recombinant human Transthyretin protein

products description :

Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.

ncbi gi num :

4507725

ncbi acc num :

NP_000362.1

ncbi gb acc num :

NM_000371.3

uniprot acc num :

P02766

ncbi mol weight :

15,887 Da

ncbi pathways :

Amyloid Fiber Formation Pathway (1269169); Disease Pathway (1268854); Diseases Associated With Visual Transduction Pathway (1268929); Diseases Of Signal Transduction Pathway (1268855); Extracellular Matrix Organization Pathway (1270244); FOXA2 And FOXA3 Transcription Factor Networks Pathway (137911); Metabolism Pathway (1269956); Metabolism Of Fat-soluble Vitamins Pathway (1339147); Metabolism Of Proteins Pathway (1268677); Metabolism Of Vitamins And Cofactors Pathway (1270144)

ncbi summary :

This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc. [provided by RefSeq, Jan 2009]

uniprot summary :

TTR: Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. Defects in TTR are the cause of amyloidosis transthyretin-related (AMYL-TTR). A hereditary generalized amyloidosis due to transthyretin amyloid deposition. Protein fibrils can form in different tissues leading to amyloid polyneuropathies, amyloidotic cardiomyopathy, carpal tunnel syndrome, systemic senile amyloidosis. The disease includes leptomeningeal amyloidosis that is characterized by primary involvement of the central nervous system. Neuropathologic examination shows amyloid in the walls of leptomeningeal vessels, in pia arachnoid, and subpial deposits. Some patients also develop vitreous amyloid deposition that leads to visual impairment (oculoleptomeningeal amyloidosis). Clinical features include seizures, stroke-like episodes, dementia, psychomotor deterioration, variable amyloid deposition in the vitreous humor. Defects in TTR are a cause of hyperthyroxinemia dystransthyretinemic euthyroidal (HTDE). It is a condition characterized by elevation of total and free thyroxine in healthy, euthyroid persons without detectable binding protein abnormalities. Defects in TTR are a cause of carpal tunnel syndrome type 1 (CTS1). It is a condition characterized by entrapment of the median nerve within the carpal tunnel. Symptoms include burning pain and paresthesias involving the ventral surface of the hand and fingers which may radiate proximally. Impairment of sensation in the distribution of the median nerve and thenar muscle atrophy may occur. This condition may be associated with repetitive occupational trauma, wrist injuries, amyloid neuropathies, rheumatoid arthritis. Belongs to the transthyretin family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 18q12.1. Cellular Component: cytoplasm; extracellular region; extracellular space; protein complex. Molecular Function: hormone activity; hormone binding; identical protein binding; protein binding; protein heterodimerization activity. Biological Process: cellular protein metabolic process; extracellular matrix organization and biogenesis; fat-soluble vitamin metabolic process; phototransduction, visible light; retinoid metabolic process; retinol metabolic process; transport; vitamin metabolic process. Disease: Amyloidosis, Hereditary, Transthyretin-related; Carpal Tunnel Syndrome; Hyperthyroxinemia, Dystransthyretinemic

size1 :

0.05 mg

price1 :

160 USD

size2 :

0.1 mg

price2 :

235

more info or order :

MyBioSource product webpage