Recombinant Mouse 1,25-dihydroxyvitamin D (3) 24-hydroxylase, mitochondrial (Cyp24a1) | MyBioSource MBS1485620 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Mouse 1,25-dihydroxyvitamin D (3) 24-hydroxylase, mitochondrial (Cyp24a1)

catalog :

MBS1485620

quantity :

0.5 mg (E-Coli)

price :

1265 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS1485620

products type :

Recombinant Protein

products full name :

Recombinant Mouse 1,25-dihydroxyvitamin D (3) 24-hydroxylase, mitochondrial (Cyp24a1)

products short name :

1,25-dihydroxyvitamin D (3) 24-hydroxylase, mitochondrial (Cyp24a1)

products name syn :

1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial; 24-OHase; Vitamin D(3) 24-hydroxylase; EC=1.14.13.126; Cytochrome P450 24A1; Cytochrome P450-CC24

other names :

1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial; 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial; 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial; 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial; cytochrome P450, 24; cytochrome P450 24A1; cytochrome P450-CC24; cytochrome P450, 24a1; vitamin D(3) 24-hydroxylase; 25-hydroxyvitamin D-24-hydroxylase; cytochrome P450, family 24, subfamily a, polypeptide 1; Cytochrome P450 24A1; Cytochrome P450-CC24

products gene name :

Cyp24a1

products gene name syn :

Cyp24a1; Cyp-24; Cyp24

other gene names :

Cyp24a1; Cyp24a1; CP24; Cyp24; 24-OHase; Cyp-24; Cyp24; 24-OHase; Vitamin D(3) 24-hydroxylase

uniprot entry name :

CP24A_MOUSE

host :

E Coli or Yeast or Baculovirus or Mammalian Cell

sequence positions :

36-514

sequence length :

479

sequence :

RAPKE VPLCPLMTDG ETRNVTSLPG PTNWPLLGSL LEIFWKGGLK KQHDTLAEYH KKYGQIFRMK LGSFDSVHLG SPSLLEALYR TESAHPQRLE IKPWKAYRDH RNEAYGLMIL EGQEWQRVRS AFQKKLMKPV EIMKLDKKIN EVLADFMGQI DELRDERGRI QDLYSELNKW SFESICLVLY EKRFGLLQKD TEEEALTFIA AIKTMMSTFG KMMVTPVELH KRLNTKVWQA HTLAWDTIFK SVKPCIDHRL ERYSQQPGAD FLCDIYQQDH LSKKELYAAV TELQLAAVET TANSLMWILY NLSRNPQVQQ RLLREIQSVL PDNQTPRAED VRNMPYLKAC LKESMRLTPS VPFTTRTLDK PTVLGEYTLP KGTVLTLNTQ VLGSSEDNFE DADKFRPERW LEKEKKINPF AHLPFGVGKR MCIGRRLAEL QLHLALCWII QKYNIVATDS EPVEMLHLGI LVPSRELPIA FCPR

purity :

>90%

form :

Liquid containing glycerol; lyophilization may be available upon request.

storage stability :

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

other info1 :

Species: Mus musculus (Mouse)

ncbi gi num :

6753572

ncbi acc num :

NP_034126.1

ncbi gb acc num :

NM_009996.3

uniprot acc num :

Q64441

ncbi mol weight :

59,453 Da

ncbi pathways :

Biological Oxidations Pathway (926856); Cytochrome P450 Pathway (198390); Cytochrome P450 - Arranged By Substrate Type Pathway (926858); Metabolism Pathway (926669); Metabolism Of Lipids And Lipoproteins Pathway (926687); Metabolism Of Steroid Hormones And Vitamin D Pathway (926732); Metapathway Biotransformation (198377); MicroRNAs In Cancer Pathway (852715); MicroRNAs In Cancer Pathway (852928); Nuclear Receptors In Lipid Metabolism And Toxicity Pathway (198356)

ncbi summary :

The protein encoded by this gene localizes to the mitochondrion, where it degrades calcitriol to calcitetrol. This gene is upregulated by binding of calcitriol to the upstream regulatory region and to a downstream enhancer region, thereby allowing calcitriol to autoregulate its concentration in the cell. The encoded protein may also play a role in calcium homeostasis. [provided by RefSeq, Aug 2015]

uniprot summary :

CYP24A1: Has a role in maintaining calcium homeostasis. Catalyzes the NADPH-dependent 24-hydroxylation of calcidiol (25- hydroxyvitamin D(3)) and calcitriol (1-alpha,25-dihydroxyvitamin D(3)). The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid. It also shows 23- hydroxylating activity leading to 1-alpha,25-dihydroxyvitamin D(3)-26,23-lactone as end product. Defects in CYP24A1 are the cause of hypercalcemia infantile (HCAI). HCAI is a disorder characterized by abnormally high level of calcium in the blood, failure to thrive, vomiting, dehydration, and nephrocalcinosis. Belongs to the cytochrome P450 family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Oxidoreductase; Mitochondrial; EC 1.14.13.126. Cellular Component: mitochondrion. Molecular Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; iron ion binding; metal ion binding; heme binding; 25-hydroxycholecalciferol-24-hydroxylase activity; oxidoreductase activity; 1-alpha,25-dihydroxyvitamin D3 (1,25-(OH)2D3) 24-hydroxylase activity; monooxygenase activity. Biological Process: response to vitamin D; vitamin D metabolic process

size1 :

0.5 mg (E-Coli)

price1 :

1265 USD

size2 :

0.05 mg (Baculovirus)

price2 :

1265

size3 :

0.5 mg (Yeast)

price3 :

1480

size4 :

0.05 mg (Mammalian-Cell)

price4 :

1480

size5 :

1 mg (E-Coli)

price5 :

2065

more info or order :

MyBioSource product webpage