catalog number :
MBS1469441
products type :
Recombinant Protein
products full name :
Recombinant Human Sterile alpha and TIR motif-containing protein 1 (SARM1)
products short name :
[Sterile alpha and TIR motif-containing protein 1 (SARM1)]
other names :
[sterile alpha and TIR motif-containing protein 1; Sterile alpha and TIR motif-containing protein 1; sterile alpha and TIR motif-containing protein 1; sterile alpha and TIR motif containing 1; Sterile alpha and Armadillo repeat protein; Sterile alpha motif domain-containing protein 2; MyD88-5; SAM domain-containing protein 2; Tir-1 homolog]
products gene name :
[SARM1]
products gene name syn :
[SARM1]
other gene names :
[SARM1; SARM1; SARM; SAMD2; MyD88-5; KIAA0524; SAMD2; SARM; MyD88-5; SAM domain-containing protein 2]
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
sequence positions :
[28-724. Full Length of Mature Protein]
sequence :
LAVPGPDGGGGTGPWWAAGGRGPREVSPGAGTEVQDALE
RALPELQQALSALKQAGGARAVGAGLAEVFQLVEEAWLL
PAVGREVAQGLCDAIRLDGGLDLLLRLLQAPELETRVQA
ARLLEQILVAENRDRVARIGLGVILNLAKEREPVELARS
VAGILEHMFKHSEETCQRLVAAGGLDAVLYWCRRTDPAL
LRHCALALGNCALHGGQAVQRRMVEKRAAEWLFPLAFSK
EDELLRLHACLAVAVLATNKEVEREVERSGTLALVEPLV
ASLDPGRFARCLVDASDTSQGRGPDDLQRLVPLLDSNRL
EAQCIGAFYLCAEAAIKSLQGKTKVFSDIGAIQSLKRLV
SYSTNGTKSALAKRALRLLGEEVPRPILPSVPSWKEAEV
QTWLQQIGFSKYCESFREQQVDGDLLLRLTEEELQTDLG
MKSGITRKRFFRELTELKTFANYSTCDRSNLADWLGSLD
PRFRQYTYGLVSCGLDRSLLHRVSEQQLLEDCGIHLGVH
RARILTAAREMLHSPLPCTGGKPSGDTPDVFISYRRNSG
SQLASLLKVHLQLHGFSVFIDVEKLEAGKFEDKLIQSVM
GARNFVLVLSPGALDKCMQDHDCKDWVHKEIVTALSCGK
NIVPIIDGFEWPEPQVLPEDMQAVLTFNGIKWSHEYQEA
TIEKIIRFLQGRSSRDSSAGSDTSLEGAAPMGPT
form :
Liquid containing glycerol
storage stability :
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
other info1 :
Species: Human
other info2 :
Storage Buffer: Tris-based buffer, 50% glycerol
ncbi acc num :
NP_055892.2
ncbi gb acc num :
NM_015077.3
ncbi mol weight :
75,337 Da
ncbi pathways :
Activated TLR4 Signalling Pathway (106400); Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway (187088); IKK Complex Recruitment Mediated By RIP1 Pathway (187090); Immune System Pathway (106386); Innate Immune System Pathway (106387); MyD88-independent Cascade Pathway (106401); TRAF6 Mediated Induction Of TAK1 Complex Pathway (187091); TRIF-mediated TLR3/TLR4 Signaling Pathway (187089); Toll Like Receptor 3 (TLR3) Cascade Pathway (106391); Toll Like Receptor 4 (TLR4) Cascade Pathway (106398)
uniprot summary :
Negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway which plays a pivotal role in activating axonal degeneration following injury. Promotes Wallerian degeneration an injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site. Can activate neuronal death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response. Inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38.
size1 :
0.05 mg (Baculovirus)
size2 :
0.1 mg (Baculovirus)
size3 :
0.5 mg (Baculovirus)
size4 :
1 mg (Baculovirus)
size9 :
0.05 mg (Mammalian-Cell)
size13 :
0.1 mg (Mammalian-Cell)