Recombinant Human Deoxyribonuclease gamma (DNASE1L3) | MyBioSource MBS1467924 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Deoxyribonuclease gamma (DNASE1L3)

catalog :

MBS1467924

quantity :

0.01 mg (E-Coli)

price :

200 USD

more info or order :

MyBioSource product webpage

image

image 1 :

product information

catalog number :

MBS1467924

products type :

Recombinant Protein

products full name :

Recombinant Human Deoxyribonuclease gamma (DNASE1L3)

products short name :

[Deoxyribonuclease gamma (DNASE1L3)]

products name syn :

[DNase I homolog protein DHP2; Deoxyribonuclease I-like 3; DNase I-like 3; Liver and spleen Dnase; LS-Dnase; LSD]

other names :

[deoxyribonuclease gamma isoform 2; Deoxyribonuclease gamma; deoxyribonuclease gamma; deoxyribonuclease I-like 3; DNase I homolog protein DHP2; Deoxyribonuclease I-like 3; DNase I-like 3; Liver and spleen DNase; LS-DNase; LSD]

products gene name :

[DNASE1L3]

other gene names :

[DNASE1L3; DNASE1L3; LSD; DHP2; SLEB16; DNAS1L3; DHP2; DNAS1L3; DNase gamma; DNase I-like 3; LS-DNase; LSD]

uniprot entry name :

DNSL3_HUMAN

host :

E Coli or Yeast or Baculovirus or Mammalian Cell

sequence positions :

[21-305. Full Length of Mature Protein]

sequence :

MRICSFNVRSFGESKQEDKNAMDVIVKVIKRCDIILVME
IKDSNNRICPILMEKLNRNSRRGITYNYVISSRLGRNTY
KEQYAFLYKEKLVSVKRSYHYHDYQDGDADVFSREPFVV
WFQSPHTAVKDFVIIPLHTTPETSVKEIDELVEVYTDVK
HRWKAENFIFMGDFNAGCSYVPKKAWKNIRLRTDPRFVW
LIGDQEDTTVKKSTNCAYDRIVLRGQEIVSSVVPKSNSV
FDFQKAYKLTEEEALDVSDHFPVEFKLQSSRAFTNSKKS
VTLRKKTKSKRS

purity :

Greater than 90% as determined by SDS-PAGE.

form :

Liquid containing glycerol

storage stability :

Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

image1 heading :

SDS-Page

other info2 :

Species: Homo sapiens (Human). Production Note: Special Offer: The E Coli host-expressed protein is manufactured from a stock plasmid containing the protein gene. E Colihost-expressed protein is stocked in different unit sizes ranging from as small as 10 ug to as large as 1 mg. Bulk inventory is also available. The E Coli host-expressed protein has been ordered over and over again by researchers and has stood the test of time as both a robust protein and important target for the research community. It is part of our new program to make our most popular protein targets and corresponding hosts available in expanded unit sizes and with a quick processing time. Select E Coli host-expressed protein for the fastest delivery among all hosts. Please contact our technical support team or email to support@mybiosource.com for more details.

products categories :

Cell Biology

products description :

Has DNA hydrolytic activity. Does not bind to actin. Cleaves chromatin DNA to nucleosomal units.

products references :

Identification, localization, and expression of two novel human genes similar to deoxyribonuclease I." Rodriguez A.M., Rodin D., Nomura H., Morton C.C., Weremowicz S., Schneider M.C. Genomics 42:507-513(1997)

ncbi gi num :

375151549

ncbi acc num :

NP_001243489.1

ncbi gb acc num :

NM_001256560.1

uniprot acc num :

Q13609

ncbi mol weight :

60.04kD

ncbi summary :

This gene encodes a member of the deoxyribonuclease I family. The encoded protein hydrolyzes DNA, is not inhibited by actin, and mediates the breakdown of DNA during apoptosis. Mutations in this gene are a cause of systemic lupus erythematosus-16. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

uniprot summary :

DNASE1L3: Has DNA hydrolytic activity. Does not bind to actin. Cleaves chromatin DNA to nucleosomal units. Defects in DNASE1L3 are the cause of systemic lupus erythematosus type 16 (SLEB16). A rare autosomal recessive form of systemic lupus erythematosus with childhood onset, characterized by high frequency of anti-neutrophil cytoplasmic antibodies and lupus nephritis. Systemic lupus erythematosus is a chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Belongs to the DNase I family. Protein type: EC 3.1.21.-; Secreted, signal peptide; Calcium-binding; Deoxyribonuclease; Apoptosis; Secreted. Chromosomal Location of Human Ortholog: 3p14.3. Cellular Component: nucleus. Molecular Function: calcium ion binding; deoxyribonuclease activity; DNA binding; endodeoxyribonuclease activity, producing 5'-phosphomonoesters. Biological Process: DNA fragmentation during apoptosis; DNA metabolic process. Disease: Systemic Lupus Erythematosus 16

size1 :

0.01 mg (E-Coli)

price1 :

200 USD

size2 :

0.01 mg (Baculovirus)

price2 :

255

size3 :

0.05 mg (E-Coli)

price3 :

260

size4 :

0.02 mg (Baculovirus)

price4 :

395

size5 :

0.1 mg (E-Coli)

price5 :

430

size6 :

0.2 mg (E-Coli)

price6 :

685

size7 :

0.05 mg (Baculovirus)

price7 :

755

size8 :

0.05 mg (Yeast)

price8 :

820

size9 :

0.1 mg (Baculovirus)

price9 :

1040

size10 :

0.2 mg (Yeast)

price10 :

1105

size11 :

0.5 mg (E-Coli)

price11 :

1125

size12 :

0.5 mg (Yeast)

price12 :

1250

size13 :

0.05 mg (Mammalian-Cell)

price13 :

1275

size14 :

0.5 mg (Baculovirus)

price14 :

1480

size15 :

1 mg (E-Coli)

price15 :

1725

size16 :

1 mg (Yeast)

price16 :

1970

size17 :

1 mg (Baculovirus)

price17 :

2060

size18 :

0.1 mg (Mammalian-Cell)

price18 :

2070

more info or order :

MyBioSource product webpage