protein

Recombinant Human Cathepsin-E

MBS146601

0.005 mg

140 USD

Recombinant Protein

Recombinant Human Cathepsin-E

[Cathepsin-E]

[Cathepsin E, EC 3.4.23.34, CATE, Erythrocyte Membrane Aspartic Proteinase, Slow-Moving Proteinase, EC 3.4.23.]

[cathepsin E; Cathepsin E; cathepsin E; erythrocyte membrane aspartic proteinase; slow-moving proteinase; cathepsin E]

[CTSE]

[CTSE; CTSE; CATE]

CATE_HUMAN

396

MGSSHHHHHH SSGLVPRGSH MGS TESCSMD QSAKEPLINY LDMEYFGTIS IGSPPQNFTV IFDTGSSNLWVPSVYCTSPA CKTHSRFQPS QSSTYSQPGQ SFSIQYGTGS LSGIIGADQV SVEGLTVVGQ QFGESVTEPGQTFVDAEFDG ILGLGYPSLA VGGVTPVFDN MMAQNLVDLP MFSVYMSSNP EGGAGSELIF GGYDHSHFSG SLNWVPVTKQ AYWQIALDNMLWSVPTLTSC RMSPSPLTES PIPSAQLPTP YWTSWMECSS AAVAFKDLTS TLQLGPSGSW GMSSFDSFTQSLTVGITVWD WPQQSPKEGP CVCACLSDRP

Greater than 85% as determined by SDS-PAGE.

Sterile Filtered clear solution. CTSE protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M urea and 10% glycerol.

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze thaw cycles.

Source: Escherichia Coli.

ENZYMES

CTSE Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 330 amino acids (57-363 a.a) and having a molecular mass of 35.4 kDa. CTSE is fused to a 23 amino acid His-tag at N-terminus & purified by propietary chromatographic techniques.

181194

AAA52130.1

Adaptive Immune System Pathway (366160); Immune System Pathway (106386); Lysosome Pathway (99052); Lysosome Pathway (96865); MHC Class II Antigen Presentation Pathway (645290)

The protein encoded by this gene is a gastric aspartyl protease that functions as a disulfide-linked homodimer. This protease, which is a member of the peptidase C1 family, has a specificity similar to that of pepsin A and cathepsin D. It is an intracellular proteinase that does not appear to be involved in the digestion of dietary protein and is found in highest concentration in the surface of epithelial mucus-producing cells of the stomach. It is the first aspartic proteinase expressed in the fetal stomach and is found in more than half of gastric cancers. It appears, therefore, to be an oncofetal antigen. Transcript variants utilizing alternative polyadenylation signals and two transcript variants encoding different isoforms exist for this gene. [provided by RefSeq, Jul 2008]

CTSE: May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain. Belongs to the peptidase A1 family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: EC 3.4.23.34; Protease. Chromosomal Location of Human Ortholog: 1q31. Cellular Component: endosome. Molecular Function: protein homodimerization activity; aspartic-type endopeptidase activity. Biological Process: protein autoprocessing; digestion; antigen processing and presentation of exogenous peptide antigen via MHC class II; proteolysis

0.005 mg

140 USD

0.02 mg

205

1 mg

2665