catalog number :
MBS1465161
products type :
Recombinant Protein
products full name :
Recombinant Human Ecto-NOX disulfide-thiol exchanger 2 (ENOX2)
products short name :
[Ecto-NOX disulfide-thiol exchanger 2 (ENOX2)]
other names :
[ecto-NOX disulfide-thiol exchanger 2 isoform a; Ecto-NOX disulfide-thiol exchanger 2; ecto-NOX disulfide-thiol exchanger 2; ecto-NOX disulfide-thiol exchanger 2; APK1 antigen; Cytosolic ovarian carcinoma antigen 1; Tumor-associated hydroquinone oxidase; tNOX]
products gene name :
[ENOX2]
products gene name syn :
[ENOX2]
other gene names :
[ENOX2; ENOX2; APK1; tNOX; COVA1; COVA1; tNOX]
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
sequence positions :
[1-610aa, full length protein]
sequence :
MQRDFRWLWVYEIGYAADNSRTLNVDSTAMTLPMSDPTA
WATAMNNLGMAPLGIAGQPILPDFDPALGMMTGIPPITP
MMPGLGIVPPPIPPDMPVVKEIIHCKSCTLFPPNPNLPP
PATRERPPGCKTVFVGGLPENGTEQIIVEVFEQCGEIIA
IRKSKKNFCHIRFAEEYMVDKALYLSGYRIRLGSSTDKK
DTGRLHVDFAQARDDLYEWECKQRMLAREERHRRRMEEE
RLRPPSPPPVVHYSDHECSIVAEKLKDDSKFSEAVQTLL
TWIERGEVNRRSANNFYSMIQSANSHVRRLVNEKAAHEK
DMEEAKEKFKQALSGILIQFEQIVAVYHSASKQKAWDHF
TKAQRKNISVWCKQAEEIRNIHNDELMGIRREEEMEMSD
DEIEEMTETKETEESALVSQAEALKEENDSLRWQLDAYR
NEVELLKQEQGKVHREDDPNKEQQLKLLQQALQGMQQHL
LKVQEEYKKKEAELEKLKDDKLQVEKMLENLKEKESCAS
RLCASNQDSEYPLEKTMNSSPIKSEREALLVGIISTFLH
VHPFGASIEYICSYLHRLDNKICTSDVECLMGRLQHTFK
QEMTGVGASLEKRWKFCGFEGLKLT
form :
Liquid containing glycerol
storage stability :
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
other info1 :
Species: Human
other info2 :
Storage Buffer: Tris-based buffer, 50% glycerol
products description :
This protein is a growth-related cell surface protein. It was identifed because it reacts with the monoclonal antibody KI in cells, such as the ovarian carcinoma line OVCAR-3, also expressing the CAKI surface glycoprotein. The encoded protein has two enzymatic activities: catalysis of hydroquinone or NADH oxidation, and protein disulfide interchange. The two activities alternate with a period length of about 24 minutes. The encoded protein also displays prion-like properties. Two transcript variants encoding different isoforms have been found for this gene.
ncbi acc num :
NP_001268665.1
ncbi gb acc num :
NM_001281736.1
ncbi mol weight :
66,621 Da
ncbi summary :
This gene is a tumor-specific member of the ECTO-NOX family of genes that encode cell surface NADH oxidases. The encoded protein has two enzymatic activities: catalysis of hydroquinone or NADH oxidation, and protein disulfide interchange. The protein also displays prion-like properties. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
uniprot summary :
May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock.
size3 :
0.05 mg (Baculovirus)
size7 :
0.05 mg (Mammalian-Cell)
size9 :
0.1 mg (Baculovirus)
size11 :
0.5 mg (Baculovirus)
size12 :
0.1 mg (Mammalian-Cell)
size14 :
1 mg (Baculovirus)