protein

Recombinant Human Mannose-6-Phosphate Receptor

MBS146450

0.002 mg

140 USD

Recombinant Protein

Recombinant Human Mannose-6-Phosphate Receptor

Mannose-6-Phosphate Receptor

mannose 6-phosphate receptor; Cation-independent mannose-6-phosphate receptor; cation-independent mannose-6-phosphate receptor; 300 kDa mannose 6-phosphate receptor; CI Man-6-P receptor; CI-MPR; IGF-II receptor; M6P/IGF2 receptor; M6P/IGF2R; M6PR; MPR 300; cation-independent mannose-6 phosphate receptor; insulin-like growth factor II receptor; insulin-like growth factor 2 receptor; 300 kDa mannose 6-phosphate receptor; MPR 300; Insulin-like growth factor 2 receptor; Insulin-like growth factor II receptor; IGF-II receptor; M6P/IGF2 receptor; M6P/IGF2R; CD_antigen: CD222

M6PR

IGF2R; IGF2R; MPR1; MPRI; CD222; CIMPR; M6P-R; MPRI; CI Man-6-P receptor; CI-MPR; M6PR; MPR 300; IGF-II receptor; M6P/IGF2R

MPRI_HUMAN

Escherichia Coli

2491

MGSSHHHHHH SSGLVPRGSH MGSTEEKTCD LVGEKGKESE KELALVKRLK PLFNKSFEST VGQGSDTYIY IFRVCREAGN HTSGAGLVQI NKSNGKETVV GRLNETHIFN GSNWIMLIYK GGDEYDNHCG KEQRRAVVMI SCNRHTLADN FNPVSEERGK VQDCFYLFEM DSSLACSPEI SH.

Greater than 85.0% as determined by SDS-PAGE.

The M6PR solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT

0.5mg/ml

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

Physical Appearance: Sterile Filtered clear solution.

RECOMBINANT & NATURAL PROTEINS

Introduction: Mannose-6-Phosphate Receptor (M6PR) belongs to the P-type lectin family. P-type lectins play a vital role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The M6PR protein functions as a homodimer and needs divalent cations for ligand binding. Lysosomal enzymes carrying phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the ensuing receptor-ligand complex is transferred to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. Description: M6PR Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 182 amino acids (27-185) and having a molecular mass of 20.3kDa. M6PR is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

188672

AAA59866.1

Clathrin Derived Vesicle Budding Pathway (119545); Golgi Associated Vesicle Biogenesis Pathway (119546); Lysosome Pathway (99052); Lysosome Pathway (96865); Membrane Trafficking Pathway (106160); Trans-Golgi Network Vesicle Budding Pathway (106165)

This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate, although the binding sites for either are located on different segments of the receptor. This receptor functions in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. While the related mouse gene shows exclusive expression from the maternal allele, imprinting of the human gene appears to be polymorphic, with only a minority of individuals showing expression from the maternal allele. [provided by RefSeq, Apr 2013]

IGF2R: a multifunctional type I transmembrane protein receptor that binds insulin-like growth factor 2 at the cell surface and mannose-6-phosphate-tagged proteins in the trans-Golgi network. Also known as the cation-independent mannose-6 phosphate (M6P) receptor. Clears IGF2 from the cell surface to attenuate signaling, and transports M6P-tagged lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. M6P-tagged lysosomal enzymes bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Belongs to the MRL1/IGF2R family. Protein type: Vesicle; Receptor, misc.; Membrane protein, integral. Chromosomal Location of Human Ortholog: 6q26. Cellular Component: extracellular space; cell surface; focal adhesion; clathrin coat; lysosomal membrane; integral to plasma membrane; trans-Golgi network; trans-Golgi network transport vesicle; membrane; perinuclear region of cytoplasm; nuclear envelope lumen; endocytic vesicle; late endosome; endosome. Molecular Function: G-protein coupled receptor activity; mannose binding; identical protein binding; protein binding; retinoic acid binding; enzyme binding; transporter activity; phosphoprotein binding; G-protein alpha-subunit binding; receptor activity; glycoprotein binding; insulin-like growth factor II binding; insulin-like growth factor receptor activity. Biological Process: G-protein coupled receptor protein signaling pathway; receptor-mediated endocytosis; organ regeneration; response to retinoic acid; insulin-like growth factor receptor signaling pathway; positive regulation of apoptosis; spermatogenesis; liver development; signal transduction; post-embryonic development. Disease: Hepatocellular Carcinoma

0.002 mg

140 USD

0.01 mg

205

1 mg

5015