protein

Recombinant Human Nucleolin

MBS146265

0.002 mg

140 USD

Recombinant Protein

Recombinant Human Nucleolin

[Nucleolin]

[Nucleolin; Protein C23; NCL; C23]

[nucleolin; Nucleolin; nucleolin; nucleolin; Protein C23]

[NCL]

[NCL; NCL; C23]

NUCL_HUMAN

710

Greater than 80.0% as determined by SDS-PAGE.

NCL (0.79 mg/ml)is supplied in 20mM HEPES buffer pH-7.3, 600mM NaCl, 0.3mM Tris(2-carboxyethyl) Phosphine (TCEP) and 25% glycerol.

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. Avoid multiple freeze-thaw cycles.

Source: Sf9 Insect Cells. Physical Appearance: Sterile Filtered clear solution.

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins

Description: Nucleolin Human Recombinant produced in SF9 is a glycosylated, polypeptide chain containing the C-terminal section of the human nucleolin and missing the N-terminal histone-binding part of nucleolin, having a calculated molecular mass of 55,162 Dalton. NCL is expressed with a -6x His tag at N-terminus and purified by proprietary chromatographic techniques. Introduction: Nucleolin (NCL) which is a eukaryotic nucleolar phosphoprotein, involved in the synthesis and maturation of ribosomes. Nucleolin is the key nucleolar protein of growing eukaryotic cells. NCL is found linked with intranucleolar chromatin and pre-ribosomal particles. NCL induces chromatin decondensation by binding to histone H1. Nucleolin is assumed to have a role in pre-rRNA transcription and ribosome compilation. Nucleolin may also have a role in the process of transcriptional elongation. Nucleolin is located primarily in the dense fibrillar regions of the nucleolus. The Human NCL gene consists of 14 exons with 13 introns and spans approximately 11kb.

55956788

NP_005372.2

NM_005381.2

P19338

76,614 Da

Aurora B Signaling Pathway (138080); Pathogenic Escherichia Coli Infection Pathway (83103); Pathogenic Escherichia Coli Infection Pathway (672459); Pathogenic Escherichia Coli Infection Pathway (516); Regulation Of Telomerase Pathway (137987); Validated Targets Of C-MYC Transcriptional Activation Pathway (169351)

Nucleolin (NCL), a eukaryotic nucleolar phosphoprotein, is involved in the synthesis and maturation of ribosomes. It is located mainly in dense fibrillar regions of the nucleolus. Human NCL gene consists of 14 exons with 13 introns and spans approximately 11kb. The intron 11 of the NCL gene encodes a small nucleolar RNA, termed U20. [provided by RefSeq, Jul 2008]

NCL: the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and preribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-RNA transcription and ribosome assembly. Protein type: Nuclear receptor co-regulator; DNA-binding; RNA-binding; Nucleolus; Helicase. Chromosomal Location of Human Ortholog: 2q37.1. Cellular Component: nucleoplasm; membrane; nucleolus; cell cortex; nucleus; ribonucleoprotein complex. Molecular Function: protein C-terminus binding; identical protein binding; protein binding; RNA binding; nucleotide binding; telomeric DNA binding. Biological Process: angiogenesis

0.002 mg

140 USD

0.01 mg

205

1 mg

5015