protein

Recombinant Rhesus Macaque Eotaxin (CCL11); Eotaxin Rhesus Macaque

MBS146184

0.005 mg

140 USD

Recombinant Protein

Recombinant Rhesus Macaque Eotaxin (CCL11); Eotaxin Rhesus Macaque

[Eotaxin]

[Small inducible cytokine A11, CCL11, Eosinophil chemotactic protein, chemokine (C-C motif) ligand 11, SCYA11, MGC22554]

[Eotaxin; Eotaxin; eotaxin; C-C motif chemokine 11; chemokine CCL11/EOTAXIN; small-inducible cytokine A11; C-C motif chemokine 11; Small-inducible cytokine A11]

[CCL11; CCL11; SCYA11; Eotaxin; SCYA11]

CCL11_MACMU

97

GPDSVATTCC FTLTNKKIPL QRLESYRRII SGKCPQKAVI FKTKLAKDIC ADPKKKWVQD SMKYLDRKSP TPKP

Greater than 98.0% as determined by:. (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE

The Eotaxin was lyophilized from a 0.2 um filtered concentrated solution in 2xPBS, pH 7.0

Lyophilized Eotaxin although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Eotaxin should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Source: E.coli. Physical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.

Solubility: It is recommended to reconstitute the lyophilized Eotaxin Recombinant in sterile distilled H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions. Biological Activity: Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human peripheral blood eosinophils is in a concentration range of 0.1-10.0 ng/ml corresponding to a specific activity of 1.0 x 10^5 - 1.0 x 10^7 IU/mg.

CHEMOKINES; Chemokines; Eotaxin

Description: Recombinant Eotaxin Rhesus Macaque produced in E Coli cells is a non-glycosylated, homodimeric protein containing 74 amino acid chain and having a molecular mass of 8.4kDa. The Eotaxin is purified by proprietary chromatographic techniques. Introduction: Chemokine (C-C motif) ligand 11 (CCL11) is a small cytokine belonging to the CC chemokine family that is also known as eotaxin. CCL11 selectively recruits eosinophils by inducing their chemotaxis, and therefore, is implicated in allergic responses. The effects of CCL11 are mediated by its binding to a G-protein-linked receptor known as a chemokine receptor. Chemokine receptors for which CCL11 is a ligand include CCR2, CCR3 and CCR5. The gene for human CCL11 (scya11) is encoded on three exons and is located on chromosome 17.

46395900

Q8MIT7.1

Q8MIT7

Asthma Pathway (86786); Asthma Pathway (532); Chemokine Signaling Pathway (99278); Chemokine Signaling Pathway (96864); Cytokine-cytokine Receptor Interaction Pathway (86721); Cytokine-cytokine Receptor Interaction Pathway (460)

In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3 ().

0.005 mg

140 USD

0.02 mg

205

1 mg

2665