Recombinant Human Mercaptopyruvate Sulfurtransferase MPST Human | MyBioSource MBS146125 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Mercaptopyruvate Sulfurtransferase MPST Human

catalog :

MBS146125

quantity :

0.005 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS146125

products type :

Recombinant Protein

products full name :

Recombinant Human Mercaptopyruvate Sulfurtransferase MPST Human

products short name :

[Mercaptopyruvate Sulfurtransferase]

products name syn :

[3-mercaptopyruvate sulfurtransferase, MST, MPST, TST2]

other names :

[3-mercaptopyruvate sulfurtransferase isoform 2; 3-mercaptopyruvate sulfurtransferase; 3-mercaptopyruvate sulfurtransferase; human liver rhodanese; tRNA thiouridin modification protein 1; mercaptopyruvate sulfurtransferase]

products gene name :

[MPST]

other gene names :

[MPST; MPST; MST; TST2; TUM1; TST2; MST]

uniprot entry name :

THTM_HUMAN

host :

E Coli

sequence :

MGSSHHHHHH SSGLVPRGSH MGSH MASPQL CRALVSAQWV AEALRAPRAG QPLQLLDASW YLPKLGRDAR REFEERHIPG AAFFDIDQCS DRTSPYDHML PGAEHFAEYA GRLGVGAATH VVIYDASDQG LYSAPRVWWM FRAFGHHAVS LLDGGLRHWL RQNLPLSSGK SQPAPAEFRA QLDPAFIKTY EDIKENLESR RFQVVDSRAT GRFRGTEPEP RDGIEPGHIP GTVNIPFTDF LSQEGLEKSP EEIRHLFQEK KVDLSKPLVA TCGSGVTACH VALGAYLCGK PDVPIYDGSW VEWYMRARPE DVISEGRGKT H.

purity :

Greater than 95.0% as determined by SDS-PAGE.

form :

The MPST solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 20% glycerol and 1mM DTT

storage stability :

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

other info1 :

Physical Appearance: Sterile Filtered clear solution

products categories :

ENZYMES; Enzymes; Transferase

products description :

Description: MPST Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 321 amino acids (1-297) and having a molecular mass of 35kDa.MPST is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. Introduction: Mercaptopyruvate Sulfurtransferase (MPST) catalyzes the transfer of a sulfur ion from 3-mercaptopyruvate to cyanide or other thiol compounds. MPST might be involved in cysteine degradation and cyanide detoxification. The MPST enzyme is regulated by oxidative stress and thioredoxin. In oxidative stress conditions, the catalytic cysteine site is transformed to a sulfenate which inhibits the MPST enzyme activity. The reduced thioredoxin cleaves an intersubunit disulfide bond to activate the redox switch and reactivate the enzyme. A deficiency in MPST activity is implicated in a rare inheritable condition known as MCDU (mercaptolactate-cysteine disulfiduria).

ncbi gi num :

61835204

ncbi acc num :

NP_001013454.1

ncbi gb acc num :

NM_001013436.2

uniprot acc num :

P25325

ncbi pathways :

Cysteine And Methionine Metabolism Pathway (104488); Cysteine And Methionine Metabolism Pathway (103421); Metabolic Pathways (132956); Sulfur Metabolism Pathway (83026); Sulfur Metabolism Pathway (417); Sulfur Relay System Pathway (172845); Sulfur Relay System Pathway (171866); Trans-sulfuration Pathway (739008)

ncbi summary :

This protein encoded by this gene catalyzes the transfer of a sulfur ion from 3-mercaptopyruvate to cyanide or other thiol compounds. It may be involved in cysteine degradation and cyanide detoxification. There is confusion in literature between this protein (mercaptopyruvate sulfurtransferase, MPST), which appears to be cytoplasmic, and thiosulfate sulfurtransferase (rhodanese, TST, GeneID:7263), which is a mitochondrial protein. Deficiency in MPST activity has been implicated in a rare inheritable disorder known as mercaptolactate-cysteine disulfiduria (MCDU). Alternatively spliced transcript variants encoding same or different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

MPST: Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. May have a role in cyanide degradation or in thiosulfate biosynthesis. Protein type: Transferase; Amino Acid Metabolism - cysteine and methionine; EC 2.8.1.2; Mitochondrial. Chromosomal Location of Human Ortholog: 22q13.1. Cellular Component: neuron projection; mitochondrial inner membrane; synapse; cell junction. Molecular Function: 3-mercaptopyruvate sulfurtransferase activity; thiosulfate sulfurtransferase activity. Biological Process: cyanate catabolic process; response to toxin

size1 :

0.005 mg

price1 :

140 USD

size2 :

0.02 mg

price2 :

205

size3 :

1 mg

price3 :

2665

more info or order :

MyBioSource product webpage