catalog number :
MBS146033
products type :
Recombinant Protein
products full name :
Recombinant Human Cathelicidin Antimicrobial Peptide
products short name :
Cathelicidin Antimicrobial
products name syn :
CAMP Human; Cathelicidin Antimicrobial Peptide Human Recombinant; CAP-18; CAP18; CRAMP; FALL-39; FALL39; HSD26; LL37; 18 kDa cationic antimicrobial protein; FALL-39 peptide antibiotic; Cathelicidin antimicrobial peptide
other names :
cathelicidin antimicrobial peptide preproprotein; Cathelicidin antimicrobial peptide; cathelicidin antimicrobial peptide; 18 kDa cationic antimicrobial protein; cathelicidin antimicrobial peptide; 18 kDa cationic antimicrobial protein; CAP-18; hCAP-18
products gene name :
CAMP
other gene names :
CAMP; CAMP; LL37; CAP18; CRAMP; HSD26; CAP-18; FALL39; FALL-39; CAP18; FALL39; CAP-18; hCAP-18
uniprot entry name :
CAMP_HUMAN
sequence :
MGSSHHHHHH SSGLVPRGSH MGSQVLSYKE AVLRAIDGIN QRSSDANLYR LLDLDPRPTM DGDPDTPKPV SFTVKETVCP RTTQQSPEDC DFKKDGLVKR CIVlGTVTLNQA RGSFDISCDK NKRFALLGD FFRKSKEKIG KEFKRIVQRIKDFLRNLVPR TES.
purity :
Greater than 90.0% as determined by SDS-PAGE.
form :
CAMP protein solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M UREA and 10% glycerol. Sterile Filtered clear solution.
storage stability :
Store at 4 degree C if entire vial will be used withing 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1 HSA or BSA). Avoid multiple freeze-thaw cycles.
products categories :
RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins
products description :
Description: CAMP Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 163 amino acids (34-173 a.a.) and having a molecular mass of 18.4kDa.CAMP is fused to a 23 amino acid His-tag at N-terminus. Introduction: CAMP belongs to the antimicrobial peptide family, contains highly conserved N-terminal signal peptide, a cathelin domain and a structurally variable cationic antimicrobial peptide that produced by extracellular proteolysis from the C-terminus. CAMP has numerous functions besides the antimicrobial activity such as: cell chemotaxis, immune mediator induction and inflammatory response regulation.
ncbi acc num :
NP_004336.3
ncbi gb acc num :
NM_004345.4
ncbi mol weight :
19,301 Da
ncbi pathways :
Disease Pathway (530764); Integrated Pancreatic Cancer Pathway (711360); Latent Infection Of Homo Sapiens With Mycobacterium Tuberculosis Pathway (645267); Phagosomal Maturation (early Endosomal Stage) Pathway (645268); SREBP Signalling Pathway (219802); Salivary Secretion Pathway (153376); Salivary Secretion Pathway (153352); Tuberculosis Pathway (213780); Tuberculosis Pathway (213743)
ncbi summary :
This gene encodes a member of an antimicrobial peptide family, characterized by a highly conserved N-terminal signal peptide containing a cathelin domain and a structurally variable cationic antimicrobial peptide, which is produced by extracellular proteolysis from the C-terminus. In addition to its antibacterial, antifungal, and antiviral activities, the encoded protein functions in cell chemotaxis, immune mediator induction, and inflammatory response regulation. [provided by RefSeq, Sep 2014]
uniprot summary :
CAMP: Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity. Belongs to the cathelicidin family. Protein type: Cell cycle regulation; Secreted, signal peptide; Vesicle; Secreted. Chromosomal Location of Human Ortholog: 3p21.3. Cellular Component: extracellular space; specific granule; cell projection; cell wall; cytosol. Molecular Function: protein binding. Biological Process: interaction with host; positive regulation of angiogenesis; defense response to Gram-positive bacterium; innate immune response in mucosa; killing by host of symbiont cells; defense response to bacterium; positive regulation of cell proliferation; antibacterial humoral response; positive regulation of protein amino acid phosphorylation; defense response to Gram-negative bacterium