catalog number :
MBS1457639
products type :
Recombinant Protein
products full name :
Recombinant Influenza A virus (strain A/Mallard/New York/6750/1978 H2N2) Hemagglutinin
products short name :
Hemagglutinin
products name syn :
Cleaved into the following 2 chains: 1. Hemagglutinin HA1 chain; 2. Hemagglutinin HA2 chain
other names :
Hemagglutinin; Hemagglutinin
uniprot entry name :
HEMA_I78A3
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
sequence positions :
16-339
sequence :
DQICIGYHANNSTEKVDTILERNVTVTHAKDILEKTHNG
KLCRLSGIPPLELGDCSIAGWLLGNPECDRLLSVPEWSY
IVEKENPANGLCYPGNFNDYEELKHLLTRVTHFEKIKIL
PRDQWTQHTTTGGSRACAVSGNPSFFRNMVWLTKKGSNY
PVAKGSYNNTSGEQMLVIWGIHHPNDDTEQRTLYQNVGT
YVSVGTSTLNKRSIPEIATRPKVNGQGGRMEFSWTLLET
WDVINFESTGNLIAPEYGFKISKRGSSGIMKTEKTLENC
ETKCQTPLGAINTTLPFHNIHPLTIGECPKYVKSDRLVL
ATGLRNVPQIES
purity :
Greater than 90% as determined by SDS-PAGE.
form :
Liquid containing glycerol; lyophilization may be available upon request.
storage stability :
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
other info2 :
Species: Influenza A virus (strain A/Mallard/New York/6750/1978 H2N2)
products categories :
Microbiology
products description :
Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore
products references :
Origin of the pandemic 1957 H2 influenza A virus and the persistence of its possible progenitors in the avian reservoir."
Schafer J.R., Kawaoka Y., Bean W.J., Suss J., Senne D., Webster R.G.
Virology 194:781-788(1993)
ncbi mol weight :
52.18kD
size5 :
0.05 mg (Baculovirus)