protein

Recombinant Human CD46

MBS145606

0.005 mg

140 USD

Recombinant Protein

Recombinant Human CD46

[CD46]

[CD46 Human; CD46 Human Recombinant; AHUS2; MCP; MIC10; TLX; TRA2.10; Membrane cofactor protein; Trophoblast leukocyte common antigen; CD46]

[membrane cofactor protein isoform 1; Membrane cofactor protein; membrane cofactor protein; CD46 antigen, complement regulatory protein; antigen identified by monoclonal antibody TRA-2-10; complement membrane cofactor protein; measles virus receptor; membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen); trophoblast leucocyte common antigen; trophoblast leukocyte common antigen; CD46 molecule, complement regulatory protein; TLX; Trophoblast leukocyte common antigen; CD_antigen: CD46]

[CD46]

[CD46; CD46; MCP; TLX; AHUS2; MIC10; TRA2.10; MCP; MIC10]

MCP_HUMAN

E Coli

MGSSHHHHHH SSGLVPRGSH MGS CEEPPTF EAMELIGKPK PYYEIGERVD YKCKKGYFYI PPLATHTICD RNHTWLPVSD DACYRETCPY IRDPLNGQAV PANGTYEFGY QMHFICNEGY YLIGEEILYC ELKGSVAIWS GKPPICEKVL CTPPPKIKNG KHTFSEVEVF EYLDAVTYSC DPAPGPDPFS LIGESTIYCG DNSVWSRAAP ECKVVKCRFP VVENGKQISG FGKKFYYKAT VMFECDKGFY LDGSDTIVCD SNSTWDPPVP KCLKGPRPTY KPPVSNYPGY PKPEEGILDS LD

Greater than 85% as determined by SDS-PAGE.

CD46 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.1M NaCl and 20% glycerol.

0.5mg/ml

RECOMBINANT & NATURAL PROTEINS; CD Antigens

Description: CD46 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 302 amino acids (35-313 a.a) and having a molecular mass of 33.8kDa. CD46 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. Introduction: Membrane cofactor protein isoform 14 (CD46), is a type I membrane protein which has cofactor activity for inactivation of complement components C3b and C4b by serum factor I. This function resides in the complement control protein repeats (CCPs), with CCP14 vital for regulation. CD46 is also involved in the fusion of the spermatozoa with the oocyte during fertilization. CD46 is common in thymocytes, T cells, B cells, monocytes, granulocytes, NK cells, platelets, endothelial cells, epithelial cells, fibroblasts, placenta and sperm.

27502402

NP_002380.3

NM_002389.4

P15529

36,826 Da

Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Complement Cascade Pathway (106405); Immune System Pathway (106386); Innate Immune System Pathway (106387); Measles Pathway (213306); Measles Pathway (213277); Regulation Of Complement Cascade Pathway (576254)

The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010]

CD46: Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement- mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T- cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46. Defects in CD46 are a cause of susceptibility to hemolytic uremic syndrome atypical type 2 (AHUS2). An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype. Patients with CD46 mutations seem to have an overall better prognosis compared to patients carrying CFH mutations. 16 isoforms of the human protein are produced by alternative splicing. Protein type: Cell surface; Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 1q32. Cellular Component: Golgi apparatus; inner acrosomal membrane; cell surface; focal adhesion; basolateral plasma membrane; integral to plasma membrane; plasma membrane. Molecular Function: enzyme inhibitor activity; complement binding; protein binding; cadherin binding; endopeptidase activity; receptor activity. Biological Process: positive regulation of memory T cell differentiation; adaptive immune response; positive regulation of regulatory T cell differentiation; viral reproduction; regulation of Notch signaling pathway; negative regulation of complement activation; single fertilization; T cell mediated immunity; negative regulation of catalytic activity; regulation of complement activation; interleukin-10 production; innate immune response; positive regulation of T cell proliferation; proteolysis; complement activation, classical pathway; positive regulation of interleukin-10 production

0.005 mg

140 USD

0.02 mg

205

1 mg

2665