Recombinant Human Casein Kinase 1 alpha 1 | MyBioSource MBS145550 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Casein Kinase 1 alpha 1

catalog :

MBS145550

quantity :

0.005 mg

price :

140 USD

more info or order :

MyBioSource product webpage

image

image 1 :

product information

catalog number :

MBS145550

products type :

Recombinant Protein

products full name :

Recombinant Human Casein Kinase 1 alpha 1

products short name :

[Casein Kinase 1 alpha 1]

products name syn :

[CSNK1A1 Human; Casein Kinase 1 alpha 1 Human Recombinant; Casein kinase I isoform alpha; CKI-alpha; CK1; CSNK1A1; HLCDGP1; PRO2975]

other names :

[casein kinase I isoform alpha isoform 1; Casein kinase I isoform alpha; casein kinase I isoform alpha; CKI-alpha; clock regulator kinase; down-regulated in lung cancer; epididymis secretory sperm binding protein Li 77p; casein kinase 1, alpha 1; CK1]

products gene name :

[CSNK1A1]

other gene names :

[CSNK1A1; CSNK1A1; CK1; CK1a; CKIa; HLCDGP1; PRO2975; HEL-S-77p; CKI-alpha]

uniprot entry name :

KC1A_HUMAN

host :

E Coli

sequence :

MGSSHHHHHH SSGLVPRGSH MASSSGSKAE FIVGGKYKLV RKIGSGSFGD IYLAINITNG EEVAVKLESQ KARHPQLLYE SKLYKILQGG VGIPHIRWYG QEKDYNVLVM DLLGPSLEDL FNFCSRRFTM KTVLMLADQM ISRIEYVHTK NFIHRDIKPD NFLMGIGRHC NKLFLIDFGL AKKYRDNRTR QHIPYREDKN LTGTARYASI NAHLGIEQSR RDDMESLGYV LMYFNRTSLP WQGLKAATKK QKYEKISEKK MSTPVEVLCK GFPAEFAMYL NYCRGLRFEE APDYMYLRQL FRILFRTLNH QYDYTFDWTM LKQKAAQQAA SSSGQGQQAQ TPTGKQTDKT KSNMKGF

purity :

Greater than 80% as determined by SDS-PAGE.

form :

The CSNK1A1 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol. Sterile Filtered colorless solution.

concentration :

0.5mg/ml

storage stability :

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

image1 heading :

SDS-PAGE

products categories :

PROTEIN KINASES; Enzymes; Casein Kinase

products description :

Description: CSNK1A1 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 357 amino acids (1-337) and having a molecular mass of 41kDa. CSNK1A1 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. Introduction: Caseine Kinase 1 alpha belongs is a member of the protein kinase superfamily, CK1 Ser/Thr protein kinase family, Casein kinase I subfamily. The CK1 isoforms - alpha, beta, gamma, delta, epsilon and their splice variants are involved in diverse cellular processes including membrane trafficking, circadian rhythm, cell cycle progression, chromosome segregation, apoptosis and cellular differentiation. Possibly CSNK1A1 can phosphorylate a large number of proteins and is involved in Wnt signaling where it phosphorylates CTNNB1 on Ser45. CSNK1A1 also interacts with the Axin complex.

ncbi gi num :

68303575

ncbi acc num :

NP_001020276.1

ncbi gb acc num :

NM_001025105.2

uniprot acc num :

P48729

ncbi mol weight :

37,567 Da

ncbi pathways :

AMER1 Mutants Destabilize The Destruction Complex Pathway (1127621); APC Truncation Mutants Are Not K63 Polyubiquitinated Pathway (1127616); APC Truncation Mutants Have Impaired AXIN Binding Pathway (1127617); AXIN Missense Mutants Destabilize The Destruction Complex Pathway (1127620); AXIN Mutants Destabilize The Destruction Complex, Activating WNT Signaling Pathway (1127618); Activation Of SMO Pathway (1127544); Beta-catenin Phosphorylation Cascade Pathway (106512); Canonical Wnt Signaling Pathway (138032); Degradation Of GLI2 By The Proteasome Pathway (1127540); Degradation Of Beta-catenin By The Destruction Complex Pathway (106511)

uniprot summary :

CK1A: an ubiquitous protein kinase of the CK1 family. Participates in Wnt signaling. Phosphorylates beta catenin, marking it for beta-TRCp-mediated ubiquitinylation and proteasomal degradation. Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CK1; EC 2.7.11.1; CK1 group; CK1 family. Chromosomal Location of Human Ortholog: 5q32. Cellular Component: centrosome; membrane; cytoplasm; nuclear speck; mRNA cleavage and polyadenylation specificity factor complex; cytosol. Molecular Function: protein serine/threonine kinase activity; protein binding; ATP binding; protein kinase activity. Biological Process: regulation of cell shape; mitosis; peptidyl-serine phosphorylation; Wnt receptor signaling pathway; cell surface receptor linked signal transduction; cell division; signal transduction; protein amino acid phosphorylation; phagocytosis

size1 :

0.005 mg

price1 :

140 USD

size2 :

0.02 mg

price2 :

205

size3 :

1 mg

price3 :

2665

more info or order :

MyBioSource product webpage