protein

Recombinant Human CD3 Gamma

MBS145527

0.005 mg

140 USD

Recombinant Protein

Recombinant Human CD3 Gamma

[CD3 Gamma]

[CD3G Human; CD3 Gamma Human Recombinant; T-cell surface glycoprotein CD3 gamma chain; CD3-GAMMA; T3G; CD3G]

[T-cell surface glycoprotein CD3 gamma chain; T-cell surface glycoprotein CD3 gamma chain; T-cell surface glycoprotein CD3 gamma chain; CD3g antigen, gamma polypeptide (TiT3 complex); CD3g molecule, epsilon (CD3-TCR complex); T-cell antigen receptor complex, gamma subunit of T3; T-cell receptor T3 gamma chain; CD3g molecule, gamma (CD3-TCR complex); T-cell receptor T3 gamma chain; CD_antigen: CD3g]

[CD3G]

[CD3G; CD3G; T3G; IMD17; CD3-GAMMA; T3G]

CD3G_HUMAN

182

MGSSHHHHHH SSGLVPRGSH MGS QSIKGNH LVKVYDYQED GSVLLTCDAE AKNITWFKDG KMIGFLTEDK KKWNLGSNAK DPRGMYQCKG SQNKSKPLQV YYRMCQNCIE LNAATIS

Greater than 90% as determined by SDS-PAGE.

CD3G protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M urea and 10% glycerol. Sterile Filtered colorless solution.

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles

Source: E.coli.

RECOMBINANT & NATURAL PROTEINS; CD Antigens

Description: CD3G Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 117 amino acids (23-116a.a.) and having a molecular mass of 13.1kDa. CD3G is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. Introduction: CD3-gamma polypeptide is encoded by CD3 Gamma (CD3G) which together with CD3-epsilon, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, configures the T-cell receptor-CD3 complex. The T-cell receptor-CD3 complex takes part in coupling antigen recognition to numerous intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. Deficiencies in this gene are associated with T cell immunodeficiency.

4557429

NP_000064.1

NM_000073.2

P09693

Adaptive Immune System Pathway (366160); CXCR4-mediated Signaling Events Pathway (137910); Chagas Disease (American Trypanosomiasis) Pathway (147809); Chagas Disease (American Trypanosomiasis) Pathway (147795); Costimulation By The CD28 Family Pathway (119552); Downstream TCR Signaling Pathway (106418); Downstream Signaling In Naive CD8+ T Cells Pathway (138018); FCGR Activation Pathway (771578); Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway (771577); Generation Of Second Messenger Molecules Pathway (106417)

The protein encoded by this gene is the CD3-gamma polypeptide, which together with CD3-epsilon, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. Defects in this gene are associated with T cell immunodeficiency. [provided by RefSeq, Jul 2008]

CD3G: The CD3 complex mediates signal transduction. Protein type: Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 11q23. Cellular Component: T cell receptor complex; integral to plasma membrane; plasma membrane; alpha-beta T cell receptor complex. Molecular Function: receptor signaling complex scaffold activity; transmembrane receptor activity; protein heterodimerization activity; T cell receptor binding. Biological Process: protein transport; regulation of immune response; cell surface receptor linked signal transduction; T cell activation; T cell costimulation; establishment and/or maintenance of cell polarity; innate immune response; protein complex assembly; T cell receptor signaling pathway. Disease: Immunodeficiency 17

0.005 mg

140 USD

0.02 mg

205

1 mg

2665