protein

Recombinant Human Low Density Lipoprotein Receptor-Related Protein Associated Protein 1

MBS145439

0.005 mg

140 USD

Native Protein

Recombinant Human Low Density Lipoprotein Receptor-Related Protein Associated Protein 1

[Low Density Lipoprotein Receptor-Related Protein Associated Protein 1]

[Low density lipoprotein-related protein-associated protein 1 (alpha-2-macroglobulin receptor-associated protein 1), A2MRAP, HBP44, RAP, A2RAP, Alpha-2-MRAP.]

[alpha-2-macroglobulin receptor-associated protein; Alpha-2-macroglobulin receptor-associated protein; alpha-2-macroglobulin receptor-associated protein; 39 kDa receptor-associated protein; low density lipoprotein-related protein-associated protein 1 (alpha-2-macroglobulin receptor-associated protein 1); low density lipoprotein receptor-related protein associated protein 1; Low density lipoprotein receptor-related protein-associated protein 1; RAP]

[LRPAP1]

[LRPAP1; LRPAP1; RAP; MRAP; A2RAP; HBP44; MYP23; A2MRAP; alpha-2-MRAP; A2MRAP; Alpha-2-MRAP; RAP]

AMRP_HUMAN

357

MGSSHHHHHH SSGLVPRGSH MGSHM YSREK NQPKPSPKRE SGEEFRMEKL NQLWEKAQRL HLPPVRLAEL HADLKIQERD ELAWKKLKLD GLDEDGEKEA RLIRNLNVIL AKYGLDGKKD ARQVTSNSLS GTQEDGLDDP RLEKLWHKAK TSGKFSGEEL DKLWREFLHH KEKVHEYNVL LETLSRTEEI HENVISPSDL SDIKGSVLHS RHTELKEKLR SINQGLDRLR RVSHQGYSTE AEFEEPRVID LWDLAQSANL TDKELEAFRE ELKHFEAKIE KHNHYQKQLE IAHEKLRHAE SVGDGERVSR SREKHALLEG RTKELGYTVK KHLQDLSGRI SRARHNEL

Greater than 90% as determined by SDS-PAGE.

The LRPAP1 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT and 20% glycerol. Sterile Filtered colorless solution.

Store at 4°C if entire viall will be used within 2-4 weeks. Store frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein ( 0.1% HSA or BSA). Avoid multiple freeze- thaw cycles.

Source: Escherichia Coli

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins

Description: LRPAP1 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 348 amino acids (35-357) and having a molecular mass of 40.4kDa. LRPAP1 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. Introduction: LRPAP1 is a member of the alpha-2-MRAP family. LRPAP1 cooperates with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330. LRPAP1, located on the cell surface, creates a complex with the alpha 2 macroglobulin receptor light and heavy chains and has part in the pathogenesis of membrane glomerular nephritis.

4505021

NP_002328.1

NM_002337.3

P30533

Lissencephaly Gene (LIS1) In Neuronal Migration And Development Pathway (137984); Reelin Signaling Pathway (137980); Signaling Events Mediated By The Hedgehog Family Pathway (137950)

This gene encodes a protein that interacts with the low density lipoprotein (LDL) receptor-related protein and facilitates its proper folding and localization by preventing the binding of ligands. Mutations in this gene have been identified in individuals with myopia 23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

LRPAP1: Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330. In complex with the alpha-2-MR or gp330, it may have some role in the pathogenesis of membrane glomerular nephritis. Belongs to the alpha-2-MRAP family. Protein type: Receptor, misc. Chromosomal Location of Human Ortholog: 4p16.3. Cellular Component: cell surface; endoplasmic reticulum; plasma membrane; extracellular region; integral to membrane; vesicle. Molecular Function: heparin binding; protein binding; receptor antagonist activity; low-density lipoprotein receptor binding; unfolded protein binding; asialoglycoprotein receptor activity. Biological Process: vesicle-mediated transport; receptor-mediated endocytosis; protein folding; negative regulation of protein binding. Disease: Myopia 23, Autosomal Recessive

0.005 mg

140 USD

0.02 mg

205

1 mg

2665