protein

Human Bactericidal/Permeability-Increasing Protein

MBS145436

0.002 mg

140 USD

Native Protein

Human Bactericidal/Permeability-Increasing Protein

[Bactericidal/Permeability-Increasing]

[BPI Human; Bactericidal/Permeability-Increasing Protein Human; Bactericidal/permeability-increasing protein; CAP 57]

[bactericidal permeability-increasing protein; Bactericidal permeability-increasing protein; bactericidal permeability-increasing protein; BPI fold containing family D, member 1; CAP 57; recombinant BPI holoprotein, rBPI; bactericidal/permeability-increasing protein; CAP 57]

[BPI]

[BPI; BPI; rBPI; BPIFD1; BPI]

BPI_HUMAN

487

Greater than 70% as determined by SDS-PAGE and capillary electrophoresis.

BPI (1.15mg/ml) is supplied in 25mM Sodium Acetate pH-4.6.

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles.

Physical Appearance: Sterile filtered colorless solution

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins

Description: The native protein BPI is isolated from human buffy coats and has a molecular mass of 53kDa. Introduction: BPI encodes a lipopolysaccharide binding protein. BPI is related to human neutrophil granules and has bactericidal activity on gram-negative organisms.

157276599

NP_001716.2

NM_001725.2

P17213

This gene encodes a lipopolysaccharide binding protein. It is associated with human neutrophil granules and has antimicrobial activity against gram-negative organisms. [provided by RefSeq, Nov 2014]

BPI: The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. Protein type: Cell surface; Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 20q11.23. Cellular Component: integral to plasma membrane; cytoplasm. Molecular Function: lipopolysaccharide binding. Biological Process: negative regulation of interleukin-6 production; negative regulation of interleukin-8 production; immune response; negative regulation of tumor necrosis factor production; negative regulation of macrophage activation; defense response to Gram-negative bacterium

0.002 mg

140 USD

0.01 mg

205

1 mg

5015